In Vitro Antistaphylococcal Effects of Embelia schimperi Extracts and Their Component Embelin with Oxacillin and Tetracycline
Joint Authors
Patrick, Van Damme
Rondevaldova, Johana
Leuner, Olga
Teka, Alemtshay
Lulekal, Ermias
Havlik, Jaroslav
Kokoska, Ladislav
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Bacterial infections are in less-developed countries traditionally treated by remedies prepared from medicinal plants.
Embelia schimperi (Vatke) is a plant used as a taenicide or disinfectant in Ethiopia, very often taken mixed with another plant species.
In the present study, we examined two extracts prepared from seeds and twigs with leaves of E.
schimperi and its main present secondary metabolite embelin for their antibacterial combinatory effect with oxacillin and tetracycline against sensitive and resistant Staphylococcus aureus strains.
Minimum inhibitory concentrations were determined through the broth microdilution method, whereas the combinatory effect was evaluated through fractional inhibitory concentration sum (ΣFIC) indices.
Results show many positive interactions and synergy occurring in embelin and oxacillin combinations against 4 out of 9 strains (ΣFIC 0.203–0.477) and for embelin and tetracycline combination against 3 out of 9 strains (ΣFIC 0.400–0.496).
Moreover, the resistance to oxacillin has been overcome in 2 strains and to tetracycline in 3 strains.
According to our knowledge, this is the first study showing antimicrobial combinatory effect of E.
schimperi as well as of embelin.
These findings can be used for the further research targeted on the development of new antistaphylococcal agents.
American Psychological Association (APA)
Rondevaldova, Johana& Leuner, Olga& Teka, Alemtshay& Lulekal, Ermias& Havlik, Jaroslav& Patrick, Van Damme…[et al.]. 2015. In Vitro Antistaphylococcal Effects of Embelia schimperi Extracts and Their Component Embelin with Oxacillin and Tetracycline. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061208
Modern Language Association (MLA)
Rondevaldova, Johana…[et al.]. In Vitro Antistaphylococcal Effects of Embelia schimperi Extracts and Their Component Embelin with Oxacillin and Tetracycline. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061208
American Medical Association (AMA)
Rondevaldova, Johana& Leuner, Olga& Teka, Alemtshay& Lulekal, Ermias& Havlik, Jaroslav& Patrick, Van Damme…[et al.]. In Vitro Antistaphylococcal Effects of Embelia schimperi Extracts and Their Component Embelin with Oxacillin and Tetracycline. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061208
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061208