Bathing Effects of Various Seawaters on Allergic (Atopic) Dermatitis-Like Skin Lesions Induced by 2,4-Dinitrochlorobenzene in Hairless Mice
Joint Authors
Kim, Choong Gon
Kang, Meehye
Lee, Youn-Ho
Min, Won Gi
Kim, Yong Hwan
Kang, Su Jin
Song, Chang Hyun
Park, Soo Jin
Park, Ji Ha
Han, Chang Hyun
Lee, Young-Joon
Ku, Sae-Kwang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-16
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
We evaluated the preventive effects of four types of seawater collected in Republic of Korea on hairless mice with 2,4-dinitrochlorobenzene- (DNCB-) induced allergic/atopic dermatitis (AD).
The anti-inflammatory effects were evaluated by measuring tumor necrosis factor- (TNF-) α and interleukins (ILs).
Glutathione (GSH), malondialdehyde (MDA), superoxide anion, and inducible nitric oxide synthase (iNOS) were measured to evaluate the antioxidant effects.
Caspase-3 and poly (ADP-ribose) polymerase (PARP) were observed to measure the antiapoptotic effects; matrix metalloproteinase- (MMP-) 9 levels were also evaluated.
Mice with AD had markedly higher clinical skin severity scores and scratching behaviors; higher TNF-α and ILs (1β, 10, 4, 5, and 13) levels; higher MDA, superoxide anion, caspase-3, PARP, and MMP-9 levels; and greater iNOS activity.
However, the severity of AD was significantly decreased by bathing in seawaters, but it did not influence the dermal collagen depositions and skin tissue antioxidant defense systems.
These results suggest that bathing in all four seawaters has protective effects against DNCB-induced AD through their favorable systemic and local immunomodulatory effects, active cytoprotective antiapoptotic effects, inhibitory effects of MMP activity and anti-inflammatory and antioxidative effects.
American Psychological Association (APA)
Kim, Choong Gon& Kang, Meehye& Lee, Youn-Ho& Min, Won Gi& Kim, Yong Hwan& Kang, Su Jin…[et al.]. 2015. Bathing Effects of Various Seawaters on Allergic (Atopic) Dermatitis-Like Skin Lesions Induced by 2,4-Dinitrochlorobenzene in Hairless Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-25.
https://search.emarefa.net/detail/BIM-1061210
Modern Language Association (MLA)
Kim, Choong Gon…[et al.]. Bathing Effects of Various Seawaters on Allergic (Atopic) Dermatitis-Like Skin Lesions Induced by 2,4-Dinitrochlorobenzene in Hairless Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-25.
https://search.emarefa.net/detail/BIM-1061210
American Medical Association (AMA)
Kim, Choong Gon& Kang, Meehye& Lee, Youn-Ho& Min, Won Gi& Kim, Yong Hwan& Kang, Su Jin…[et al.]. Bathing Effects of Various Seawaters on Allergic (Atopic) Dermatitis-Like Skin Lesions Induced by 2,4-Dinitrochlorobenzene in Hairless Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-25.
https://search.emarefa.net/detail/BIM-1061210
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061210