Active Compounds of Rhubarb Root and Rhizome in Animal Model Experiments of Focal Cerebral Ischemia
Joint Authors
Liu, Ai-ju
Song, Liang
Li, Yan
Zhang, Xiao-guang
Chen, Zi-xian
Huang, Li-bo
Zhang, Hong-feng
Zheng, Guo-qing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Rhubarb root and rhizome (RRR) has been clinically used for stroke at least 2000 years and is still used in modern times in both China and elsewhere worldwide.
The objective of present study was to evaluate the efficacy of active compounds of RRR (ACRRR) for experimental ischemic stroke.
Studies of ACRRR in animal models of ischemic stroke were identified from 5 databases until April 2014.
Study quality for each included article was evaluated according to the CAMARADES 10-item checklist.
Outcome measures were neurological deficit score and infarct size.
All the data were analyzed using RevMan 5.1 software.
As a result, 20 studies were identified describing procedures involving 577 animals.
The quality score of studies ranges from 2 to 6, and the median was 3.4.
Six studies showed significant effects of ACRRR for improving infarct size compared with model group (P<0.01).
Six studies indicated significant effects of ACRRR for improving the neurological deficit scores according to Zea longa criterion or eight-point criterion (P<0.01).
In conclusion, these findings demonstrated a possible efficacy of ACRRR that have potential neuroprotective effect for experimental ischemic stroke.
However, these apparently positive findings should be interpreted with caution because of the methodological flaws.
American Psychological Association (APA)
Liu, Ai-ju& Song, Liang& Li, Yan& Zhang, Xiao-guang& Chen, Zi-xian& Huang, Li-bo…[et al.]. 2015. Active Compounds of Rhubarb Root and Rhizome in Animal Model Experiments of Focal Cerebral Ischemia. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1061246
Modern Language Association (MLA)
Liu, Ai-ju…[et al.]. Active Compounds of Rhubarb Root and Rhizome in Animal Model Experiments of Focal Cerebral Ischemia. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1061246
American Medical Association (AMA)
Liu, Ai-ju& Song, Liang& Li, Yan& Zhang, Xiao-guang& Chen, Zi-xian& Huang, Li-bo…[et al.]. Active Compounds of Rhubarb Root and Rhizome in Animal Model Experiments of Focal Cerebral Ischemia. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1061246
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061246