![](/images/graphics-bg.png)
Efficacy and Safety of Pomegranate Medicinal Products for Cancer
Joint Authors
Vlachojannis, Christian
Zimmermann, Benno F.
Chrubasik, Sigrun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-01
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Preclinical in vitro and in vivo studies demonstrate potent effects of pomegranate preparations in cancer cell lines and animal models with chemically induced cancers.
We have carried out one systematic review of the effectiveness of pomegranate products in the treatment of cancer and another on their safety.
The PubMed search provided 162 references for pomegranate and cancer and 122 references for pomegranate and safety/toxicity.
We identified 4 clinical studies investigating 3 pomegranate products, of which one was inappropriate because of the low polyphenol content.
The evidence of clinical effectiveness was poor because the quality of the studies was poor.
Although there is no concern over safety with the doses used in the clinical studies, pomegranate preparations may be harmful by inducing synthetic drug metabolism through activation of liver enzymes.
We have analysed various pomegranate products for their content of anthocyanins, punicalagin, and ellagic acid in order to compare them with the benchmark doses from published data.
If the amount of coactive constituents is not declared, patients risk not benefiting from the putative pomegranate effects.
Moreover, pomegranate end products are affected by many determinants.
Their declaration should be incorporated into the regulatory guidance and controlled before pomegranate products enter the market.
American Psychological Association (APA)
Vlachojannis, Christian& Zimmermann, Benno F.& Chrubasik, Sigrun. 2015. Efficacy and Safety of Pomegranate Medicinal Products for Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1061282
Modern Language Association (MLA)
Vlachojannis, Christian…[et al.]. Efficacy and Safety of Pomegranate Medicinal Products for Cancer. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1061282
American Medical Association (AMA)
Vlachojannis, Christian& Zimmermann, Benno F.& Chrubasik, Sigrun. Efficacy and Safety of Pomegranate Medicinal Products for Cancer. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1061282
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061282