Prophylactic Treatment with Adlay Bran Extract Reduces the Risk of Severe Acute Radiation Dermatitis: A Prospective, Randomized, Double-Blind Study

Joint Authors

Kan, Jung-Yu
Hu, Stephen Chu-Sung
Huang, Chih-Jen
Juan, Chiung-Hui
Yuan, Shyng-Shiou F.
Luo, Kuei-Hau
Hou, Ming-Feng
Chuang, Hung-Yi

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-10-01

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

Acute radiation dermatitis is a frequent adverse effect in patients with breast cancer undergoing radiotherapy, but there are only a small number of studies providing evidence-based interventions for this clinical condition.

Adlay is a cereal crop that has been previously shown to have anti-inflammatory and antioxidant properties.

In this study, we seek to evaluate the effectiveness of oral prophylactic treatment with adlay bran extract in reducing the risk of severe acute radiation dermatitis.

A total of 110 patients with breast cancer undergoing radiotherapy were analyzed.

Using a prospective, randomized, double-blind design, 73 patients received oral treatment with adlay bran extract and 37 patients received olive oil (placebo).

Treatment was started at the beginning of radiation therapy and continued until the termination of radiation treatment.

Our results showed that the occurrence of severe acute radiation dermatitis (RTOG grade 2 or higher) was significantly lower in patients treated with oral adlay bran extract compared to placebo (45.2% versus 75.7%, adjusted odds ratio 0.24).

No serious adverse effects from adlay bran treatment were noted.

In conclusion, prophylactic oral treatment with adlay bran extract reduces the risk of severe acute radiation dermatitis and may have potential use in patients with breast cancer undergoing radiotherapy.

American Psychological Association (APA)

Huang, Chih-Jen& Hou, Ming-Feng& Kan, Jung-Yu& Juan, Chiung-Hui& Yuan, Shyng-Shiou F.& Luo, Kuei-Hau…[et al.]. 2015. Prophylactic Treatment with Adlay Bran Extract Reduces the Risk of Severe Acute Radiation Dermatitis: A Prospective, Randomized, Double-Blind Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061340

Modern Language Association (MLA)

Huang, Chih-Jen…[et al.]. Prophylactic Treatment with Adlay Bran Extract Reduces the Risk of Severe Acute Radiation Dermatitis: A Prospective, Randomized, Double-Blind Study. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061340

American Medical Association (AMA)

Huang, Chih-Jen& Hou, Ming-Feng& Kan, Jung-Yu& Juan, Chiung-Hui& Yuan, Shyng-Shiou F.& Luo, Kuei-Hau…[et al.]. Prophylactic Treatment with Adlay Bran Extract Reduces the Risk of Severe Acute Radiation Dermatitis: A Prospective, Randomized, Double-Blind Study. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061340

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1061340