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Antiosteoporosis Activity of New Oriental Medicine Preparation (Kyungokgo Mixed with Water Extract of Hovenia dulcis) on the Ovariectomized Mice
Joint Authors
Kim, Jong-Jin
Kang, Kyung-Yun
Yee, Sung-Tae
Hwang, Yun-Ho
Kim, Kwang-Jin
Lee, Sung-Ju
Jeong, Gil-Yeon
Choi, Kyung-Hee
Son, Young-Jin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-09
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Protective effect of new oriental medicine (Kyungokgo mixed with water extract of Hovenia dulcis, KOGHD) was assessed on the bone loss induced mice by ovariectomy.
In the in vivo experiments, antiosteoporosis effect of KOGHD was investigated using ovariectomized osteoporosis mice model.
After 6 weeks of treatment, the mice were euthanized, and the effect of Kyungokgo (KOG) and KOGHD on body weight, spleen weigh, thymus weight, uterine weight, serum biochemical indicators, bone weight and length, immune cell population, bone morphometric parameters, and histological stains was observed.
Our results showed that KOGHD prevented the deterioration of trabecular microarchitecture caused by ovariectomy, which were accompanied by the lower levels of bone turnover markers and immune cell population as evidenced by the inhibition of RANKL-mediated osteoclast differentiation without cytotoxic effect on bone marrow derived macrophages (BMMs).
Therefore, these results suggest that the Hovenia dulcis (HD) supplementation in the KOG may also prevent and treat bone loss.
American Psychological Association (APA)
Hwang, Yun-Ho& Kim, Kwang-Jin& Kim, Jong-Jin& Kang, Kyung-Yun& Lee, Sung-Ju& Jeong, Gil-Yeon…[et al.]. 2015. Antiosteoporosis Activity of New Oriental Medicine Preparation (Kyungokgo Mixed with Water Extract of Hovenia dulcis) on the Ovariectomized Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1061422
Modern Language Association (MLA)
Hwang, Yun-Ho…[et al.]. Antiosteoporosis Activity of New Oriental Medicine Preparation (Kyungokgo Mixed with Water Extract of Hovenia dulcis) on the Ovariectomized Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1061422
American Medical Association (AMA)
Hwang, Yun-Ho& Kim, Kwang-Jin& Kim, Jong-Jin& Kang, Kyung-Yun& Lee, Sung-Ju& Jeong, Gil-Yeon…[et al.]. Antiosteoporosis Activity of New Oriental Medicine Preparation (Kyungokgo Mixed with Water Extract of Hovenia dulcis) on the Ovariectomized Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1061422
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061422