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In Vitro Ion Chelating, Antioxidative Mechanism of Extracts from Fruits and Barks of Tetrapleura tetraptera and Their Protective Effects against Fenton Mediated Toxicity of Metal Ions on Liver Homogenates
Joint Authors
Stoller, Marco
Moukette, Bruno Moukette
Pieme, Anatole Constant
Biapa, Prosper Cabral Nya
Njimou, Jacques Romain
Bravi, Marco
Yonkeu Ngogang, Jeanne
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-18
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The aim of the present study was to investigate the antioxidant activity and protective potential of T.
tetraptera extracts against ion toxicity.
The antioxidant activity of the extracts was investigated spectrophotometrically against several radicals (1,1-diphenyl-2-picrylhydrazyl (DPPH•), 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS•), hydroxyl radical (HO•), and nitric oxide (NO•)), followed by the ferric reducing power, total phenols, flavonoid, and flavonol contents.
The effects of the extracts on catalase (CAT), superoxide dismutase (SOD), and peroxidase activities were also determined using the standard methods as well as the polyphenol profile using HPLC.
The results showed that the hydroethanolic extract of T.
tetraptera (CFH) has the lowest IC50 value with the DPPH, ABTS, OH, and NO radicals.
The same extract also exhibited the significantly higher level of total phenols (37.24 ± 2.00 CAE/g dried extract); flavonoids (11.36 ± 1.88 QE/g dried extract); and flavonols contents (3.95 ± 0.39 QE/g dried extract).
The HPLC profile of T.
tetraptera revealed that eugenol (958.81 ± 00 mg/g DW), quercetin (353.78 ± 00 mg/g DW), and rutin (210.54 ± 00 mg/g DW) were higher in the fruit than the bark extracts.
In conclusion, extracts from T.
tetraptera may act as a protector against oxidative mediated ion toxicity.
American Psychological Association (APA)
Moukette, Bruno Moukette& Pieme, Anatole Constant& Biapa, Prosper Cabral Nya& Njimou, Jacques Romain& Stoller, Marco& Bravi, Marco…[et al.]. 2015. In Vitro Ion Chelating, Antioxidative Mechanism of Extracts from Fruits and Barks of Tetrapleura tetraptera and Their Protective Effects against Fenton Mediated Toxicity of Metal Ions on Liver Homogenates. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1061486
Modern Language Association (MLA)
Moukette, Bruno Moukette…[et al.]. In Vitro Ion Chelating, Antioxidative Mechanism of Extracts from Fruits and Barks of Tetrapleura tetraptera and Their Protective Effects against Fenton Mediated Toxicity of Metal Ions on Liver Homogenates. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1061486
American Medical Association (AMA)
Moukette, Bruno Moukette& Pieme, Anatole Constant& Biapa, Prosper Cabral Nya& Njimou, Jacques Romain& Stoller, Marco& Bravi, Marco…[et al.]. In Vitro Ion Chelating, Antioxidative Mechanism of Extracts from Fruits and Barks of Tetrapleura tetraptera and Their Protective Effects against Fenton Mediated Toxicity of Metal Ions on Liver Homogenates. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1061486
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061486