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Hair Growth Promotion Activity and Its Mechanism of Polygonum multiflorum
Joint Authors
Zhao, Ronghua
Yu, Jie
Lin, Pei
He, Yan Ran
Li, Yunfei
Han, Ming-Nuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Polygonum multiflorum Radix (PMR) has long history in hair growth promotion and hair coloring in clinical applications.
However, several crucial problems in its clinic usage and mechanisms are still unsolved or lack scientific evidences.
In this research, C57BL/6J mice were used to investigate hair growth promotion activity and possible mechanism of PMR and Polygonum multiflorum Radix Preparata (PMRP).
Hair growth promotion activities were investigated by hair length, hair covered skin ratio, the number of follicles, and hair color.
Regulation effects of several cytokines involved in the hair growth procedure were tested, such as fibroblast growth factor (FGF-7), Sonic Hedgehog (SHH), β-catenin, insulin-like growth factor-1 (IGF-1), and hepatocyte growth factor (HGF).
Oral PMR groups had higher hair covered skin ratio (100 ± 0.00%) than oral PMRP groups (48%~88%).
However, topical usage of PMRP had about 90% hair covered skin ratio.
Both oral administration of PMR and topically given PMRP showed hair growth promotion activities.
PMR was considered to be more suitable for oral administration, while PMRP showed greater effects in external use.
The hair growth promotion effect of oral PMR was most probably mediated by the expression of FGF-7, while topical PMRP promoted hair growth by the stimulation of SHH expression.
American Psychological Association (APA)
Li, Yunfei& Han, Ming-Nuan& Lin, Pei& He, Yan Ran& Yu, Jie& Zhao, Ronghua. 2015. Hair Growth Promotion Activity and Its Mechanism of Polygonum multiflorum. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1062476
Modern Language Association (MLA)
Li, Yunfei…[et al.]. Hair Growth Promotion Activity and Its Mechanism of Polygonum multiflorum. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1062476
American Medical Association (AMA)
Li, Yunfei& Han, Ming-Nuan& Lin, Pei& He, Yan Ran& Yu, Jie& Zhao, Ronghua. Hair Growth Promotion Activity and Its Mechanism of Polygonum multiflorum. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1062476
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1062476