Effects of Shenque Moxibustion on Behavioral Changes and Brain Oxidative State in Apolipoprotein E-Deficient Mice
Joint Authors
Huang, Jian
Liu, Juntian
Cui, Yingxue
Huang, Chang
Han, Li
Huang, Yuhai
Zhao, Baixiao
Lao, Lixing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
To determine whether moxibustion influences the learning and memory behavior of ApoE−/− male mice, and investigate the mechanism of moxibustion on the alteration of oxidized proteins (glial fibrillary acidic protein, β-amyloid) in hippocampus.
Methods.
Thirty-three ApoE−/− mice were randomly divided into 3 groups (n=11/group): moxibustion, sham moxibustion, and no treatment control.
Wild-type C57BL/6 mice n=13 were used for normal control.
Moxibustion was performed with Shenque (RN8) moxibustion for 20 minutes per day, 6 days/week for 12 weeks.
In sham control, the procedure was similar except burning of the moxa stick.
Behavioral tests (step-down test and Morris water maze task) were conducted in the 13th week.
The mice were then sacrificed and the tissues were harvested for immune-histochemical staining.
Results.
In the step-down test, the moxibustion group had shorter reaction time in training record and committed less mistakes compared to sham control.
In immune-histochemical study, the moxibustion group expressed lower level of GFAP and less aggregation of β-amyloid in the hippocampus than the sham control.
Conclusion.
Our findings suggest that moxibustion may enhance learning capability of ApoE−/− mice.
The mechanism may be via inhibiting oxidized proteins (GFAP and β-amyloid) in astrocytes.
American Psychological Association (APA)
Liu, Juntian& Zhao, Baixiao& Cui, Yingxue& Huang, Yuhai& Huang, Chang& Huang, Jian…[et al.]. 2015. Effects of Shenque Moxibustion on Behavioral Changes and Brain Oxidative State in Apolipoprotein E-Deficient Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063614
Modern Language Association (MLA)
Liu, Juntian…[et al.]. Effects of Shenque Moxibustion on Behavioral Changes and Brain Oxidative State in Apolipoprotein E-Deficient Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063614
American Medical Association (AMA)
Liu, Juntian& Zhao, Baixiao& Cui, Yingxue& Huang, Yuhai& Huang, Chang& Huang, Jian…[et al.]. Effects of Shenque Moxibustion on Behavioral Changes and Brain Oxidative State in Apolipoprotein E-Deficient Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063614
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063614