![](/images/graphics-bg.png)
Trigonellae Semen Enhances Sperm Motility and the Expression of the Cation Sperm Channel Proteins in Mouse Testes
Joint Authors
Park, Seong Kyu
Kim, Hyu Young
Chang, Mun Seog
Kim, Ha Young
Kim, Do Rim
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Genetic defects during spermatogenesis can lead to a reduction in sperm motility and cause male infertility.
The cation channels of sperm (CatSper) play a role in the regulation of hyperactivated sperm motility in mouse testes.
The effect of Trigonellae Semen (TS) on the male reproductive system and CatSper protein in mouse testes during spermatogenesis was examined.
C57BL/c mice were divided into the following five groups: normal, cyclophosphamide- (CP-) only treated (control group), and three groups treated with varying concentrations of TS with CP (100, 500, and 1000 mg/kg TS and 100 mg/kg CP).
Real-time PCR, western blot analysis, and a testosterone immunoassay were performed to assess CatSper protein levels in the five groups.
Additionally, sperm cell counts and motility were examined.
Results indicate that sperm motility and sperm counts increased in the TS treated groups in a dose-dependent manner (p<0.01).
CatSper levels were also significantly higher in the TS treated groups compared to that of the control group (p<0.001).
Therefore, TS treatment could enhance sperm function by promoting spermatogenesis and the expression of CatSper proteins in mouse testes.
American Psychological Association (APA)
Kim, Do Rim& Kim, Hyu Young& Kim, Ha Young& Chang, Mun Seog& Park, Seong Kyu. 2015. Trigonellae Semen Enhances Sperm Motility and the Expression of the Cation Sperm Channel Proteins in Mouse Testes. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063628
Modern Language Association (MLA)
Kim, Do Rim…[et al.]. Trigonellae Semen Enhances Sperm Motility and the Expression of the Cation Sperm Channel Proteins in Mouse Testes. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063628
American Medical Association (AMA)
Kim, Do Rim& Kim, Hyu Young& Kim, Ha Young& Chang, Mun Seog& Park, Seong Kyu. Trigonellae Semen Enhances Sperm Motility and the Expression of the Cation Sperm Channel Proteins in Mouse Testes. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063628
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063628