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Clinical Effect of Shenfu Injection in Patients with Septic Shock: A Meta-Analysis and Systematic Review
Joint Authors
Lv, Zheng-Tao
Mou, Zijun
Li, Yi
Wang, Meng
Xu, Qun
Yu, Xuezhong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
To conduct a meta-analysis evaluating the efficacy of Shenfu injection for treating patients with septic shock when compared with conventional therapy.
Methods.
Eight databases including Pubmed, EMBASE, Cochrane Library, ISI Web of Science, CNKI, Wanfang, VIP, and CBM were searched up to October 2014.
Randomized controlled trials assessing the efficacy of Shenfu injection were identified.
Mean arterial pressure, heart rate, lactate, and mortality were included as outcome measurements.
Results.
We analyzed data from 12 randomized controlled trials involving 904 participants.
Compared with conventional therapy, Shenfu injection could further increase the mean arterial pressure at 1 hour (SMD 0.38; 95% CI, 0.01–0.74) and 6 hours (SMD 0.82; 95% CI, 0.03–1.61).
Shenfu injection could further normalize heart rate at 6 hours (SMD −0.90; 95% CI, −1.47–0.33) and clear serum lactate at 6 hours (SMD −0.51; 95% CI, −0.70–0.32) and 24 hours (SMD, 0.52; 95% CI, −0.77–0.26).
As the endpoint of mortality was not unified, it was not meta-analyzed.
Conclusions.
Based on the findings in present review, Shenfu injection is more effective than conventional therapy in increasing mean arterial pressure, normalizing heart rate, clearing serum lactate, and reducing mortality.
These results should be confirmed in higher level clinical trials in the future.
American Psychological Association (APA)
Mou, Zijun& Lv, Zheng-Tao& Li, Yi& Wang, Meng& Xu, Qun& Yu, Xuezhong. 2015. Clinical Effect of Shenfu Injection in Patients with Septic Shock: A Meta-Analysis and Systematic Review. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063695
Modern Language Association (MLA)
Mou, Zijun…[et al.]. Clinical Effect of Shenfu Injection in Patients with Septic Shock: A Meta-Analysis and Systematic Review. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1063695
American Medical Association (AMA)
Mou, Zijun& Lv, Zheng-Tao& Li, Yi& Wang, Meng& Xu, Qun& Yu, Xuezhong. Clinical Effect of Shenfu Injection in Patients with Septic Shock: A Meta-Analysis and Systematic Review. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063695
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063695