Evaluation of a Topical Herbal Agent for the Promotion of Bone Healing
Joint Authors
Ko, Chun-Hay
Shum, Wai-Ting
Hung, Leung-Kim
Lam, Ka-Wing
Lau, David Tai-Wai
Leung, Ping-Chung
Ko, Kam Ming
Siu, Wing Sum
Lau, Clara Bik-San
Wat, Elaine
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A topically used Chinese herbal paste, namely, CDNR, was designed to facilitate fracture healing which is usually not addressed in general hospital care.
From our in vitro studies, CDNR significantly inhibited the release of nitric oxide from RAW264.7 cells by 51 to 77%.
This indicated its anti-inflammatory effect.
CDNR also promoted the growth of bone cells by stimulating the proliferation of UMR106 cells up to 18%.
It also increased the biomechanical strength of the healing bone in a drill-hole defect rat model by 16.5% significantly.
This result revealed its in vivo efficacy on facilitation of bone healing.
Furthermore, the detection of the chemical markers of CDNR in the skin and muscle of the treatment area demonstrated its transdermal properties.
However, CDNR did not affect the bone turnover markers in serum of the rats.
With its anti-inflammatory and bone formation properties, CDNR is found effective in promoting bone healing.
American Psychological Association (APA)
Siu, Wing Sum& Ko, Chun-Hay& Lam, Ka-Wing& Wat, Elaine& Shum, Wai-Ting& Lau, Clara Bik-San…[et al.]. 2015. Evaluation of a Topical Herbal Agent for the Promotion of Bone Healing. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063778
Modern Language Association (MLA)
Siu, Wing Sum…[et al.]. Evaluation of a Topical Herbal Agent for the Promotion of Bone Healing. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1063778
American Medical Association (AMA)
Siu, Wing Sum& Ko, Chun-Hay& Lam, Ka-Wing& Wat, Elaine& Shum, Wai-Ting& Lau, Clara Bik-San…[et al.]. Evaluation of a Topical Herbal Agent for the Promotion of Bone Healing. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063778
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063778