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Assessment of Antifungal Activity of Bakuchiol on Oral-Associated Candida spp.
Joint Authors
Abdul Razak, Fathilah
Wan Harun, Wan Himratul Aznita
Nordin, Mohd-Al-Faisal
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Bakuchiol is an active component of Psoralea glandulosa and Psoralea corylifolia, used in traditional Chinese medicine.
The study aimed at investigating the antifungal activity of bakuchiol on planktonic and biofilm forms of orally associated Candida species.
The antifungal susceptibility testing was determined by the broth micro dilution technique.
Growth kinetics and cell surface hydrophobicity (CSH) of Candida were measured to assess the inhibitory effect of bakuchiol on Candida planktonic cells.
Biofilm biomass and cellular metabolic activity were quantitatively estimated by the crystal violet (CV) and the 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino)carbonyl]-2H-tetrazolium hydroxide (XTT) assays.
All Candida strains have been shown to be susceptible to bakuchiol with the MIC ranges from 12.5 to 100 μg/mL.
Significant decrease in specific growth rates and viable counts demonstrates the inhibitory effect of bakuchiol on Candida planktonic cells.
A brief exposure to bakuchiol also reduced CSH of Candida ( P < 0.05 ), indicating altered surface properties of yeast cells towards hydrophobic interfaces.
Biofilm biomass and cell metabolic activity were mostly decreased, except for C.
glabrata ( P = 0.29 ).
The antifungal properties of bakuchiol on Candida species in this in vitro study may give insights into the application in therapeutic strategy against Candida infections.
American Psychological Association (APA)
Nordin, Mohd-Al-Faisal& Abdul Razak, Fathilah& Wan Harun, Wan Himratul Aznita. 2015. Assessment of Antifungal Activity of Bakuchiol on Oral-Associated Candida spp.. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063798
Modern Language Association (MLA)
Nordin, Mohd-Al-Faisal…[et al.]. Assessment of Antifungal Activity of Bakuchiol on Oral-Associated Candida spp.. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1063798
American Medical Association (AMA)
Nordin, Mohd-Al-Faisal& Abdul Razak, Fathilah& Wan Harun, Wan Himratul Aznita. Assessment of Antifungal Activity of Bakuchiol on Oral-Associated Candida spp.. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063798
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063798