Electroacupuncture Ameliorates the Coronary Occlusion Related Tachycardia and Hypotension in Acute Rat Myocardial Ischemia Model: Potential Role of Hippocampus
Joint Authors
Zhou, Meiqi
Wu, Shengbing
Cao, Jian
Zhang, Tianning
Zhou, Yiping
Wang, Keming
Zhu, Guoqi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mechanisms for electroacupuncture (EA) in disease treatments are still enigmatic.
Here, we studied whether hippocampus was involved in the protection of EA stimulation on myocardial ischemia injury.
Acute myocardial ischemia (AMI) model was produced.
EA stimulation at heart meridian from Shenmen (HT7) to Tongli (HT5) was applied to rats 3 times a day for continuous three days.
Coronary occlusion related tachycardia and hypotension, indicated by heart rate, mean arterial pressure, and rate pressure product, were apparently impaired after AMI injury.
By contrast, EA stimulating could ameliorate the impairments of heart function (P<0.05).
Interestingly, lesion of CA1 region of hippocampus abolished the protection of EA.
Neuronal activity in CA1 area was affected by AMI.
As evidenced, cell counts, cell types, and frequency of the discharged neurons were facilitated after AMI, while EA stimulation attenuated the abnormalities.
Furthermore, c-Fos expression was significantly facilitated in CA1 area after AMI, which was reduced by EA stimulation.
Correlations were established between c-Fos expression and cell counts of discharged neurons, as well as between heart function and cell counts of discharged neurons.
Taken together, EA stimulation at heart meridian protects against heart dysfunction induced by AMI possibly through suppressing the neuronal activity in CA1 region.
American Psychological Association (APA)
Wu, Shengbing& Cao, Jian& Zhang, Tianning& Zhou, Yiping& Wang, Keming& Zhu, Guoqi…[et al.]. 2015. Electroacupuncture Ameliorates the Coronary Occlusion Related Tachycardia and Hypotension in Acute Rat Myocardial Ischemia Model: Potential Role of Hippocampus. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063808
Modern Language Association (MLA)
Wu, Shengbing…[et al.]. Electroacupuncture Ameliorates the Coronary Occlusion Related Tachycardia and Hypotension in Acute Rat Myocardial Ischemia Model: Potential Role of Hippocampus. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063808
American Medical Association (AMA)
Wu, Shengbing& Cao, Jian& Zhang, Tianning& Zhou, Yiping& Wang, Keming& Zhu, Guoqi…[et al.]. Electroacupuncture Ameliorates the Coronary Occlusion Related Tachycardia and Hypotension in Acute Rat Myocardial Ischemia Model: Potential Role of Hippocampus. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063808
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063808