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Phytochemical Constituents, Antioxidant and Antiproliferative Properties of a Liverwort, Lepidozia borneensis Stephani from Mount Kinabalu, Sabah, Malaysia
Joint Authors
Abu Bakar, Mohd Fadzelly
Rahmat, Asmah
Suleiman, Monica
Isha, Azizul
Abdul Karim, Fifilyana
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The study aimed to investigate the phytochemical contents, antioxidant and antiproliferative activity of 80% methanol extract of Lepidozia borneensis.
The total phenolic and total flavonoid contents were analysed using Folin-Ciocalteu and aluminium chloride colorimetric methods.
Antioxidant properties were evaluated by using FRAP, ABTS, and DPPH assays while the effects of L.
borneensis on the proliferation of MCF-7 cell line were evaluated by using MTT assay.
The results showed that the total phenolic and flavonoid contents were 12.42 ± 0.47 mg GAE/g and 9.36 ± 1.29 mg CE/g, respectively.
The GC-MS analysis revealed the presence of at least 35 compounds.
The extract was found to induce cytotoxicity against MCF-7 cell line with IC50 value of 47.33 ± 7.37 µg/mL.
Cell cycle analysis showed that the extract induced significant arrest at G0/G1 at 24 hours of treatment.
After 72 hours of treatment, the proportion of cells in G0/G1 and G2-M phases had decreased significantly as compared to their control.
Apoptosis occurred during the first 24 hours and significantly increased to 30.8% after 72 hours of treatment.
No activation of caspase 3 was observed.
These findings suggest that L.
borneensis extract has the potential as natural antioxidant and anticancer agents.
American Psychological Association (APA)
Abu Bakar, Mohd Fadzelly& Abdul Karim, Fifilyana& Suleiman, Monica& Isha, Azizul& Rahmat, Asmah. 2015. Phytochemical Constituents, Antioxidant and Antiproliferative Properties of a Liverwort, Lepidozia borneensis Stephani from Mount Kinabalu, Sabah, Malaysia. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063819
Modern Language Association (MLA)
Abu Bakar, Mohd Fadzelly…[et al.]. Phytochemical Constituents, Antioxidant and Antiproliferative Properties of a Liverwort, Lepidozia borneensis Stephani from Mount Kinabalu, Sabah, Malaysia. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063819
American Medical Association (AMA)
Abu Bakar, Mohd Fadzelly& Abdul Karim, Fifilyana& Suleiman, Monica& Isha, Azizul& Rahmat, Asmah. Phytochemical Constituents, Antioxidant and Antiproliferative Properties of a Liverwort, Lepidozia borneensis Stephani from Mount Kinabalu, Sabah, Malaysia. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063819
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063819