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Application of Cornelian Cherry Iridoid-Polyphenolic Fraction and Loganic Acid to Reduce Intraocular Pressure
Joint Authors
Kucharska, Alicja Z.
Szumny, Dorota
Sozański, Tomasz
Dziewiszek, Wojciech
Piórecki, Narcyz
Magdalan, Jan
Chlebda-Sieragowska, Ewa
Kupczynski, Robert
Szeląg, Adam
Szumny, Antoni
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
One of the most common diseases of old age in modern societies is glaucoma.
It is strongly connected with increased intraocular pressure (IOP) and could permanently damage vision in the affected eye.
As there are only a limited number of chemical compounds that can decrease IOP as well as blood flow in eye vessels, the up-to-date investigation of new molecules is important.
The chemical composition of the dried Cornelian cherry (Cornus mas L.) polar, iridoid-polyphenol-rich fraction was investigated.
Loganic acid (50%) and pelargonidin-3-galactoside (7%) were found as the main components.
Among the other constituents, iridoid compound cornuside and the anthocyans cyanidin 3-O-galactoside, cyanidin 3-O-robinobioside, and pelargonidin 3-O-robinobioside were quantified in the fraction.
In an animal model (New Zealand rabbits), the influence of loganic acid and the polyphenolic fraction isolated from Cornelian cherry fruit was investigated.
We found a strong IOP-hypotensive effect for a 0.7% solution of loganic acid, which could be compared with the widely ophthalmologically used timolol.
About a 25% decrease in IOP was observed within the first 3 hours of use.
American Psychological Association (APA)
Szumny, Dorota& Sozański, Tomasz& Kucharska, Alicja Z.& Dziewiszek, Wojciech& Piórecki, Narcyz& Magdalan, Jan…[et al.]. 2015. Application of Cornelian Cherry Iridoid-Polyphenolic Fraction and Loganic Acid to Reduce Intraocular Pressure. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063823
Modern Language Association (MLA)
Szumny, Dorota…[et al.]. Application of Cornelian Cherry Iridoid-Polyphenolic Fraction and Loganic Acid to Reduce Intraocular Pressure. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063823
American Medical Association (AMA)
Szumny, Dorota& Sozański, Tomasz& Kucharska, Alicja Z.& Dziewiszek, Wojciech& Piórecki, Narcyz& Magdalan, Jan…[et al.]. Application of Cornelian Cherry Iridoid-Polyphenolic Fraction and Loganic Acid to Reduce Intraocular Pressure. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063823
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063823