Dezocine Prevents Postoperative Hyperalgesia in Patients Undergoing Open Abdominal Surgery
Joint Authors
Yu, Fang
Zhou, Jie
Xia, Suyun
Xu, Huan
Wang, Xiangrui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Postoperative hyperalgesia is very frequent and hard to treat.
Dezocine is widely used and has a modulatory effect for thermal hyperalgesia in animal models.
So, this study was designed to investigate the potential role of dezocine in decreasing postoperative hyperalgesia for patients undergoing open abdominal surgery.
Methods.
This is a randomized, double-blinded, and placebo-controlled trial.
50 patients for elective open gastrectomy were randomly allocated to either a true treatment group (0.15 mg/kg intravenous dezocine at the end of surgery) or a sham treatment group (equivalent volume of saline) in a 1 : 1 ratio.
Patients were followed up for 48 hours postoperatively and pain threshold to Von Frey filaments, pain scores, PCIA consumption, rescue analgesics use, sedation score, and occurrence of postoperative nausea and vomiting were recorded.
Results.
Patients in the true treatment group experienced statistically significantly higher pain threshold on forearm and smaller extent of peri-incisional hyperalgesia than the sham treatment group.
Rescue analgesic use, cumulative PCIA consumption, and pain scores were statistically significantly decreased in the true treatment group compared to the sham treatment group.
Conclusions.
Dezocine offers a significant antihyperalgesic and analgesic effect in patients undergoing elective open gastrectomy for up to 48 hours postoperatively.
American Psychological Association (APA)
Yu, Fang& Zhou, Jie& Xia, Suyun& Xu, Huan& Wang, Xiangrui. 2015. Dezocine Prevents Postoperative Hyperalgesia in Patients Undergoing Open Abdominal Surgery. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063831
Modern Language Association (MLA)
Yu, Fang…[et al.]. Dezocine Prevents Postoperative Hyperalgesia in Patients Undergoing Open Abdominal Surgery. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063831
American Medical Association (AMA)
Yu, Fang& Zhou, Jie& Xia, Suyun& Xu, Huan& Wang, Xiangrui. Dezocine Prevents Postoperative Hyperalgesia in Patients Undergoing Open Abdominal Surgery. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063831
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063831