The Adjuvant Activity of Epimedium Polysaccharide-Propolis Flavone Liposome on Enhancing Immune Responses to Inactivated Porcine Circovirus Vaccine in Mice
Joint Authors
Fan, Yunpeng
Hou, Weifeng
Guo, Liwei
Guo, Chao
Zhang, Weimin
Ma, Xia
Ma, Lin
Song, Xiaoping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
The adjuvant activity of Epimedium polysaccharide-propolis flavone liposome (EPL) was investigated in vitro and in vivo.
Methods.
In vitro, the effects of EPL at different concentrations on splenic lymphocytes proliferation and mRNA expression of IFN-γ and IL-6 were determined.
In vivo, the adjuvant activities of EPL, EP, and mineral oil were compared in BALB/c mice through vaccination with inactivated porcine circovirus type 2 (PCV2) vaccine.
Results.
In vitro, EPL promoted lymphocytes proliferation and increased the mRNA expression of IFN-γ and IL-6, and the effect was significantly better than EP at all concentrations.
In vivo, EPL significantly promoted the lymphocytes proliferation and the secretion of cytokines and improved the killing activity of NK cells, PCV2-specific antibody titers, and the proportion of T-cell subgroups.
The effects of EPL were significantly better than EP and oil adjuvant at most time points.
Conclusion.
EPL could significantly improve both PCV2-specific cellular and humoral immune responses, and its medium dose had the best efficacy.
Therefore, EPL would be exploited in an effective immune adjuvant for inactivated PCV2 vaccine.
American Psychological Association (APA)
Fan, Yunpeng& Guo, Liwei& Hou, Weifeng& Guo, Chao& Zhang, Weimin& Ma, Xia…[et al.]. 2015. The Adjuvant Activity of Epimedium Polysaccharide-Propolis Flavone Liposome on Enhancing Immune Responses to Inactivated Porcine Circovirus Vaccine in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063851
Modern Language Association (MLA)
Fan, Yunpeng…[et al.]. The Adjuvant Activity of Epimedium Polysaccharide-Propolis Flavone Liposome on Enhancing Immune Responses to Inactivated Porcine Circovirus Vaccine in Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063851
American Medical Association (AMA)
Fan, Yunpeng& Guo, Liwei& Hou, Weifeng& Guo, Chao& Zhang, Weimin& Ma, Xia…[et al.]. The Adjuvant Activity of Epimedium Polysaccharide-Propolis Flavone Liposome on Enhancing Immune Responses to Inactivated Porcine Circovirus Vaccine in Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063851