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Hepatocellular Carcinoma in Liver Cirrhosis: Surgical Resection versus Transarterial Chemoembolization—A Meta-Analysis
Joint Authors
Kapitanov, Teodor
Schmeding, Maximilian
Neumann, Ulf P.
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We compare the value of TACE to liver resection for patients with BCLC stage A and B HCC.
For patients with HCC in cirrhosis LT is the treatment of choice.
TACE represents the current standard for unresectable BCLC stage B patients not eligible for LT.
Recently liver resection for HCC and significant cirrhosis has become increasingly popular.
A systematic search of the literature and meta-analysis was conducted to identify studies, reporting short- and long-term results of hepatic resection versus TACE for HCC treatment.
The data were analyzed regarding the odds for 30-day mortality and hazard ratio for overall-survival.
12 studies comparing short- and long-term outcome of HR versus TACE for HCC were identified.
Peri-interventional mortality and overall survival were investigated.
Peri-interventional mortality was higher for surgical resection (n.s.), and overall-survival was significantly better for surgically treated patients at one year (P=0.002) and 3 years (P≤0.00001).
The hazard ratio of overall-survival for all twelve studies was 0.70 (P=0.0001) and significantly in favor of surgical treatment.
Although large RCTs are missing and the available data are limited and not homogeneous a reappraisal of the current treatment guidelines should be considered based on the superior long-term outcome for surgically treated patients.
American Psychological Association (APA)
Kapitanov, Teodor& Neumann, Ulf P.& Schmeding, Maximilian. 2015. Hepatocellular Carcinoma in Liver Cirrhosis: Surgical Resection versus Transarterial Chemoembolization—A Meta-Analysis. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1064093
Modern Language Association (MLA)
Kapitanov, Teodor…[et al.]. Hepatocellular Carcinoma in Liver Cirrhosis: Surgical Resection versus Transarterial Chemoembolization—A Meta-Analysis. Gastroenterology Research and Practice No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1064093
American Medical Association (AMA)
Kapitanov, Teodor& Neumann, Ulf P.& Schmeding, Maximilian. Hepatocellular Carcinoma in Liver Cirrhosis: Surgical Resection versus Transarterial Chemoembolization—A Meta-Analysis. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1064093
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064093