Transplantation of Autologous Mesenchymal Stem Cells for End-Stage Liver Cirrhosis: A Meta-Analysis Based on Seven Controlled Trials
Joint Authors
Ma, Xiang-Rui
Tang, Ya-Ling
Xuan, Ming
Chang, Zheng
Wang, Xiao-Yi
Liang, Xin-Hua
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
The bone marrow-derived mesenchymal stem cells (BM-MSCs) have demonstrated great potential as regenerative medicine in different therapeutic applications.
This study aims to pool previous controlled clinical trials to make an update assessment of the effectiveness of BM-MSC transplantation on end-stage liver cirrhosis.
Methods.
Relevant studies published between January 1990 and June 2014 were searched among Pubmed, Embase, and ClinicalTrial.gov.
A meta-analysis was performed to assess the effect of BM-MSCs on liver function indicators, including Models of End-Stage Liver Disease (MELD) score, serum albumin (g/L), total bilirubin (mg/dl), Prothrombin concentration (%), and alanine aminotransferase (ALT) (U/L).
Results.
BM-MSCs therapy could significantly improve liver function in patients with end-stage liver cirrhosis, in terms of MELD score, serum albumin, total bilirubin, and prothrombin concentration, at least during the half year after transplantation.
Conclusions.
Due to BM-MSCs’ immunomodulatory functions and the potential to differentiate into hepatocytes, they are a promising therapeutic agent to liver cirrhosis.
Considering currently available evidence, this therapy is relatively safe and effective in improving liver function.
However, how different variables should be controlled to optimize the therapeutic effect is still not clear.
Thus, future mechanism studies and clinical trials are required for this optimization.
American Psychological Association (APA)
Ma, Xiang-Rui& Tang, Ya-Ling& Xuan, Ming& Chang, Zheng& Wang, Xiao-Yi& Liang, Xin-Hua. 2015. Transplantation of Autologous Mesenchymal Stem Cells for End-Stage Liver Cirrhosis: A Meta-Analysis Based on Seven Controlled Trials. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1064148
Modern Language Association (MLA)
Ma, Xiang-Rui…[et al.]. Transplantation of Autologous Mesenchymal Stem Cells for End-Stage Liver Cirrhosis: A Meta-Analysis Based on Seven Controlled Trials. Gastroenterology Research and Practice No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1064148
American Medical Association (AMA)
Ma, Xiang-Rui& Tang, Ya-Ling& Xuan, Ming& Chang, Zheng& Wang, Xiao-Yi& Liang, Xin-Hua. Transplantation of Autologous Mesenchymal Stem Cells for End-Stage Liver Cirrhosis: A Meta-Analysis Based on Seven Controlled Trials. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1064148
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064148