The Effects of Viral Load Burden on Pregnancy Loss among HIV-Infected Women in the United States
Joint Authors
Westreich, Daniel J.
Cates, Jordan E.
Edmonds, Andrew
Wright, Rodney L.
Greenblatt, Ruth M.
Cejtin, Helen E.
Karim, Roksana
Haddad, Lisa B.
Kempf, Mirjam-Colette
Golub, Elizabeth T.
Adimora, Adaora A.
Minkoff, Howard
Colie, Christine
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
To evaluate the effects of HIV viral load, measured cross-sectionally and cumulatively, on the risk of miscarriage or stillbirth (pregnancy loss) among HIV-infected women enrolled in the Women’s Interagency HIV Study between 1994 and 2013.
Methods.
We assessed three exposures: most recent viral load measure before the pregnancy ended, log10 copy-years viremia from initiation of antiretroviral therapy (ART) to conception, and log10 copy-years viremia in the two years before conception.
Results.
The risk of pregnancy loss for those with log10 viral load >4.00 before pregnancy ended was 1.59 (95% confidence interval (CI): 0.99, 2.56) times as high as the risk for women whose log10 viral load was ≤1.60.
There was not a meaningful impact of log10 copy-years viremia since ART or log10 copy-years viremia in the two years before conception on pregnancy loss (adjusted risk ratios (aRRs): 0.80 (95% CI: 0.69, 0.92) and 1.00 (95% CI: 0.90, 1.11), resp.).
Conclusions.
Cumulative viral load burden does not appear to be an informative measure for pregnancy loss risk, but the extent of HIV replication during pregnancy, as represented by plasma HIV RNA viral load, predicted loss versus live birth in this ethnically diverse cohort of HIV-infected US women.
American Psychological Association (APA)
Cates, Jordan E.& Westreich, Daniel J.& Edmonds, Andrew& Wright, Rodney L.& Minkoff, Howard& Colie, Christine…[et al.]. 2015. The Effects of Viral Load Burden on Pregnancy Loss among HIV-Infected Women in the United States. Infectious Diseases in Obstetrics and Gynecology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1064376
Modern Language Association (MLA)
Cates, Jordan E.…[et al.]. The Effects of Viral Load Burden on Pregnancy Loss among HIV-Infected Women in the United States. Infectious Diseases in Obstetrics and Gynecology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1064376
American Medical Association (AMA)
Cates, Jordan E.& Westreich, Daniel J.& Edmonds, Andrew& Wright, Rodney L.& Minkoff, Howard& Colie, Christine…[et al.]. The Effects of Viral Load Burden on Pregnancy Loss among HIV-Infected Women in the United States. Infectious Diseases in Obstetrics and Gynecology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1064376
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064376