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The Estimation of First-Phase Insulin Secretion by Using Components of the Metabolic Syndrome in a Chinese Population
Joint Authors
Hsieh, Chang-Hsun
Pei, Dee
Lin, Jiunn-diann
Hsu, Chun-Hsien
Lian, Wei-Cheng
Wu, Chung-Ze
Chen, Yen-Lin
Liang, Yao-Jen
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aims.
There are two phases of insulin secretion, the first (FPIS) and second phase (SPIS).
In this study, we built equations to predict FPIS with metabolic syndrome (MetS) components and fasting plasma insulin (FPI).
Methods.
Totally, 186 participants were enrolled.
75% of participants were randomly selected as the study group to build equations.
The remaining 25% of participants were selected as the external validation group.
All participants received a frequently sampled intravenous glucose tolerance test, and acute insulin response after the glucose load (AIRg) was obtained.
The AIRg was considered as FPIS.
Results.
When MetS components were only used, the following equation was built: log (FPIS) = 1.477 − 0.119 × fasting plasma glucose (FPG) + 0.079 × body mass index (BMI) − 0.523 × high-density lipoprotein cholesterol (HDL-C).
After FPI was added, the second equation was formulated: log (FPIS) = 1.532 − 0.127 × FPG + 0.059 × BMI - 0.511 × HDL-C + 0.375 × log (FPI), which provided a better accuracy than the first one.
Conclusions.
Using MetS components, the FPIS could be estimated accurately.
After adding FPI into the equation, the predictive power increased further.
We hope that these equations could be widely used in daily practice.
American Psychological Association (APA)
Lin, Jiunn-diann& Hsu, Chun-Hsien& Liang, Yao-Jen& Lian, Wei-Cheng& Hsieh, Chang-Hsun& Wu, Chung-Ze…[et al.]. 2015. The Estimation of First-Phase Insulin Secretion by Using Components of the Metabolic Syndrome in a Chinese Population. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065777
Modern Language Association (MLA)
Lin, Jiunn-diann…[et al.]. The Estimation of First-Phase Insulin Secretion by Using Components of the Metabolic Syndrome in a Chinese Population. International Journal of Endocrinology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1065777
American Medical Association (AMA)
Lin, Jiunn-diann& Hsu, Chun-Hsien& Liang, Yao-Jen& Lian, Wei-Cheng& Hsieh, Chang-Hsun& Wu, Chung-Ze…[et al.]. The Estimation of First-Phase Insulin Secretion by Using Components of the Metabolic Syndrome in a Chinese Population. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1065777
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065777