Sesquiterpene Lactones from Artemisia Genus: Biological Activities and Methods of Analysis
Joint Authors
Ivanescu, Bianca
Corciova, Andreia
Miron, Anca
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-01
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Sesquiterpene lactones are a large group of natural compounds, found primarily in plants of Asteraceae family, with over 5000 structures reported to date.
Within this family, genus Artemisia is very well represented, having approximately 500 species characterized by the presence of eudesmanolides and guaianolides, especially highly oxygenated ones, and rarely of germacranolides.
Sesquiterpene lactones exhibit a wide range of biological activities, such as antitumor, anti-inflammatory, analgesic, antiulcer, antibacterial, antifungal, antiviral, antiparasitic, and insect deterrent.
Many of the biological activities are attributed to the α-methylene-γ-lactone group in their molecule which reacts through a Michael-addition with free sulfhydryl or amino groups in proteins and alkylates them.
Due to the fact that most sesquiterpene lactones are thermolabile, less volatile compounds, they present no specific chromophores in the molecule and are sensitive to acidic and basic mediums, and their identification and quantification represent a difficult task for the analyst.
Another problematic aspect is represented by the complexity of vegetal samples, which may contain compounds that can interfere with the analysis.
Therefore, this paper proposes an overview of the methods used for the identification and quantification of sesquiterpene lactones found in Artemisia genus, as well as the optimal conditions for their extraction and separation.
American Psychological Association (APA)
Ivanescu, Bianca& Miron, Anca& Corciova, Andreia. 2015. Sesquiterpene Lactones from Artemisia Genus: Biological Activities and Methods of Analysis. Journal of Analytical Methods in Chemistry،Vol. 2015, no. 2015, pp.1-21.
https://search.emarefa.net/detail/BIM-1067175
Modern Language Association (MLA)
Ivanescu, Bianca…[et al.]. Sesquiterpene Lactones from Artemisia Genus: Biological Activities and Methods of Analysis. Journal of Analytical Methods in Chemistry No. 2015 (2015), pp.1-21.
https://search.emarefa.net/detail/BIM-1067175
American Medical Association (AMA)
Ivanescu, Bianca& Miron, Anca& Corciova, Andreia. Sesquiterpene Lactones from Artemisia Genus: Biological Activities and Methods of Analysis. Journal of Analytical Methods in Chemistry. 2015. Vol. 2015, no. 2015, pp.1-21.
https://search.emarefa.net/detail/BIM-1067175
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067175