Relationship of Soluble RAGE with Insulin Resistance and Beta Cell Function during Development of Type 2 Diabetes Mellitus
Joint Authors
Banu, Laila Anjuman
Biswas, Subrata Kumar
Mohtarin, Sabreena
Mudi, Sonchita Rani
Anwar, Taznuva
Alam, Sheikh Md. Khorshed
Fariduddin, Md.
Arslan, M. Iqbal
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This study examined whether circulating levels of soluble receptor for advanced glycation end products (sRAGE) alter in prediabetes and correlate with insulin resistance (IR) and beta cell function in prediabetes and newly diagnosed type 2 diabetes mellitus (T2DM).
Subjects without previous history of diabetes were recruited and grouped as control, prediabetes, and newly diagnosed T2DM.
The control subjects (n=40) and people with prediabetes (n=52) and diabetes (n=66) were similar in terms of age, sex, BMI, systolic and diastolic BP, and fasting insulin level.
HOMA-IR was found significantly higher in people with diabetes than control subjects (p<0.001) and people with prediabetes (p=0.005); and HOMA-%B was found significantly deteriorated in people with diabetes (p<0.001) compared to control subjects and people with prediabetes.
However, serum sRAGE levels did not show any significant alteration in people with prediabetes compared to control subjects.
Moreover, univariate and multivariate analyses did not identify any significant correlation and statistical association of sRAGE with HOMA-IR and HOMA-%B in people with prediabetes and newly diagnosed T2DM.
Our data suggest that serum sRAGE levels do not alter in people with prediabetes compared to control subjects and do not correlate or associate with IR and beta cell function during development of T2DM.
American Psychological Association (APA)
Biswas, Subrata Kumar& Mohtarin, Sabreena& Mudi, Sonchita Rani& Anwar, Taznuva& Banu, Laila Anjuman& Alam, Sheikh Md. Khorshed…[et al.]. 2015. Relationship of Soluble RAGE with Insulin Resistance and Beta Cell Function during Development of Type 2 Diabetes Mellitus. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1067833
Modern Language Association (MLA)
Biswas, Subrata Kumar…[et al.]. Relationship of Soluble RAGE with Insulin Resistance and Beta Cell Function during Development of Type 2 Diabetes Mellitus. Journal of Diabetes Research No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1067833
American Medical Association (AMA)
Biswas, Subrata Kumar& Mohtarin, Sabreena& Mudi, Sonchita Rani& Anwar, Taznuva& Banu, Laila Anjuman& Alam, Sheikh Md. Khorshed…[et al.]. Relationship of Soluble RAGE with Insulin Resistance and Beta Cell Function during Development of Type 2 Diabetes Mellitus. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1067833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067833