Cross Talk between Lipid Metabolism and Inflammatory Markers in Patients with Diabetic Retinopathy
Joint Authors
Sergentanis, Theodoros N.
Crosby-Nwaobi, Roxanne
Dew, Tracy
Forbes, Angus
Sivaprasad, S.
Chatziralli, Irini P.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
The purpose of this study was to examine the relationship between metabolic and inflammatory markers in patients with diabetic retinopathy (DR).
Methods.
208 adult patients with type 2 diabetes participated in this study and were categorized into (1) mild nonproliferative diabetic retinopathy (NPDR) without clinically significant macular edema (CSME), (2) NPDR with CSME, (3) proliferative diabetic retinopathy (PDR) without CSME, and (4) PDR with CSME.
Variable serum metabolic markers were assessed using immunoassays.
Multinomial logistic regression analysis was performed.
Results.
Diabetes duration and hypertension are the most significant risk factors for DR.
Serum Apo-B and Apo-B/Apo-A ratio were the most significant metabolic risk factors for PDR and CSME.
For every 0.1 g/L increase in Apo-B concentration, the risk of PDR and CSME increased by about 1.20 times.
We also found that 10 pg/mL increase in serum TNF-α was associated with approximately 2-fold risk of PDR/CSME while an increase by 100 pg/mL in serum VEGF concentration correlated with CSME.
Conclusions.
In conclusion, it seems that there is a link between metabolic and inflammatory markers.
Apo-B/Apo-A ratio should be evaluated as a reliable risk factor for PDR and CSME, while the role of increased systemic TNF-α and VEGF should be explored in CSME.
American Psychological Association (APA)
Crosby-Nwaobi, Roxanne& Chatziralli, Irini P.& Sergentanis, Theodoros N.& Dew, Tracy& Forbes, Angus& Sivaprasad, S.. 2015. Cross Talk between Lipid Metabolism and Inflammatory Markers in Patients with Diabetic Retinopathy. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1067852
Modern Language Association (MLA)
Crosby-Nwaobi, Roxanne…[et al.]. Cross Talk between Lipid Metabolism and Inflammatory Markers in Patients with Diabetic Retinopathy. Journal of Diabetes Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1067852
American Medical Association (AMA)
Crosby-Nwaobi, Roxanne& Chatziralli, Irini P.& Sergentanis, Theodoros N.& Dew, Tracy& Forbes, Angus& Sivaprasad, S.. Cross Talk between Lipid Metabolism and Inflammatory Markers in Patients with Diabetic Retinopathy. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1067852
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067852