Glucocorticoid-Induced Tumour Necrosis Factor Receptor-Related Protein: A Key Marker of Functional Regulatory T Cells
Joint Authors
Ronchetti, Simona
Ricci, Erika
Cari, Luigi
Migliorati, Graziella
Nocentini, Giuseppe
Riccardi, Carlo
Petrillo, Maria Grazia
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-15
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Glucocorticoid-induced tumour necrosis factor receptor-related protein (GITR, TNFRSF18, and CD357) is expressed at high levels in activated T cells and regulatory T cells (Tregs).
In this review, we present data from mouse and human studies suggesting that GITR is a crucial player in the differentiation of thymic Tregs (tTregs), and expansion of both tTregs and peripheral Tregs (pTregs).
The role of GITR in Treg expansion is confirmed by the association of GITR expression with markers of memory T cells.
In this context, it is not surprising that GITR appears to be a marker of active Tregs, as suggested by the association of GITR expression with other markers of Treg activation or cytokines with suppressive activity (e.g., IL-10 and TGF-β), the presence of GITR+ cells in tissues where Tregs are active (e.g., solid tumours), or functional studies on Tregs.
Furthermore, some Treg subsets including Tr1 cells express either low or no classical Treg markers (e.g., FoxP3 and CD25) and do express GITR.
Therefore, when evaluating changes in the number of Tregs in human diseases, GITR expression must be evaluated.
Moreover, GITR should be considered as a marker for isolating Tregs.
American Psychological Association (APA)
Ronchetti, Simona& Ricci, Erika& Petrillo, Maria Grazia& Cari, Luigi& Migliorati, Graziella& Nocentini, Giuseppe…[et al.]. 2015. Glucocorticoid-Induced Tumour Necrosis Factor Receptor-Related Protein: A Key Marker of Functional Regulatory T Cells. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1068385
Modern Language Association (MLA)
Ronchetti, Simona…[et al.]. Glucocorticoid-Induced Tumour Necrosis Factor Receptor-Related Protein: A Key Marker of Functional Regulatory T Cells. Journal of Immunology Research No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1068385
American Medical Association (AMA)
Ronchetti, Simona& Ricci, Erika& Petrillo, Maria Grazia& Cari, Luigi& Migliorati, Graziella& Nocentini, Giuseppe…[et al.]. Glucocorticoid-Induced Tumour Necrosis Factor Receptor-Related Protein: A Key Marker of Functional Regulatory T Cells. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1068385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068385