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Recognition of Immune Response for the Early Diagnosis and Treatment of Osteoarthritis
Joint Authors
Cui, Quanjun
Kandahari, Adrese M.
Yang, Xinlin
Dighe, Abhijit S.
Pan, Dongfeng
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Osteoarthritis is a common and debilitating joint disease that affects up to 30 million Americans, leading to significant disability, reduction in quality of life, and costing the United States tens of billions of dollars annually.
Classically, osteoarthritis has been characterized as a degenerative, wear-and-tear disease, but recent research has identified it as an immunopathological disease on a spectrum between healthy condition and rheumatoid arthritis.
A systematic literature review demonstrates that the disease pathogenesis is driven by an early innate immune response which progressively catalyzes degenerative changes that ultimately lead to an altered joint microenvironment.
It is feasible to detect this infiltration of cells in the early, and presumably asymptomatic, phase of the disease through noninvasive imaging techniques.
This screening can serve to aid clinicians in potentially identifying high-risk patients, hopefully leading to early effective management, vast improvements in quality of life, and significant reductions in disability, morbidity, and cost related to osteoarthritis.
Although the diagnosis and treatment of osteoarthritis routinely utilize both invasive and non-invasive strategies, imaging techniques specific to inflammatory cells are not commonly employed for these purposes.
This review discusses this paradigm and aims to shift the focus of future osteoarthritis-related research towards early diagnosis of the disease process.
American Psychological Association (APA)
Kandahari, Adrese M.& Yang, Xinlin& Dighe, Abhijit S.& Pan, Dongfeng& Cui, Quanjun. 2015. Recognition of Immune Response for the Early Diagnosis and Treatment of Osteoarthritis. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1068397
Modern Language Association (MLA)
Kandahari, Adrese M.…[et al.]. Recognition of Immune Response for the Early Diagnosis and Treatment of Osteoarthritis. Journal of Immunology Research No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1068397
American Medical Association (AMA)
Kandahari, Adrese M.& Yang, Xinlin& Dighe, Abhijit S.& Pan, Dongfeng& Cui, Quanjun. Recognition of Immune Response for the Early Diagnosis and Treatment of Osteoarthritis. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1068397
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068397