Mesenchymal Stem Cells Immunosuppressed IL-22 in Patients with Immune Thrombocytopenia via Soluble Cellular Factors
Joint Authors
Wu, Mei
Ge, Hongfeng
Li, Shue
Chu, Hailiang
Yang, Shili
Sun, Xiaoxing
Zhou, Zhenxia
Zhu, Xiongpeng
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mesenchymal stem cells are immunoregulation cells.
IL-22 plays an important role in the pathogenesis of immune thrombocytopenia.
However, the effects of mesenchymal stem cells on IL-22 production in patients with immune thrombocytopenia remain unclear.
Flow cytometry analyzed immunophenotypes of mesenchymal stem cells; differentiation of mesenchymal stem cells was observed by oil red O and Alizarin red S staining; cell proliferation suppression was measured with MTS; IL-22 levels of cell-free supernatants were determined by ELISA.
Mesenchymal stem cells inhibited the proliferation of activated CD4+T cells; moreover, mesenchymal stem cells immunosuppressed IL-22 by soluble cellular factors but not PGE2.
These results suggest that mesenchymal stem cells may be a therapeutic strategy for patients with immune thrombocytopenia.
American Psychological Association (APA)
Wu, Mei& Ge, Hongfeng& Li, Shue& Chu, Hailiang& Yang, Shili& Sun, Xiaoxing…[et al.]. 2015. Mesenchymal Stem Cells Immunosuppressed IL-22 in Patients with Immune Thrombocytopenia via Soluble Cellular Factors. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068437
Modern Language Association (MLA)
Wu, Mei…[et al.]. Mesenchymal Stem Cells Immunosuppressed IL-22 in Patients with Immune Thrombocytopenia via Soluble Cellular Factors. Journal of Immunology Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068437
American Medical Association (AMA)
Wu, Mei& Ge, Hongfeng& Li, Shue& Chu, Hailiang& Yang, Shili& Sun, Xiaoxing…[et al.]. Mesenchymal Stem Cells Immunosuppressed IL-22 in Patients with Immune Thrombocytopenia via Soluble Cellular Factors. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068437
