Neutrophil Migration in the Activation of the Innate Immune Response to Different Flavobacterium psychrophilum Vaccines in Zebrafish (Danio rerio)
Joint Authors
Solís, Camila J.
Poblete-Morales, Matías
Cabral, Sergio
Valdés, Juan A.
Reyes, Ariel E.
Avendaño-Herrera, Ruben
Feijóo, Carmen G.
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Flavobacterium psychrophilum is a Gram-negative bacterium, responsible for the bacterial cold-water disease and the rainbow trout fry syndrome in freshwater salmonid fish.
At present, there is only one commercial vaccine in Chile, made with two Chilean F.
psychrophilum isolates and another licensed in Europe.
The present study analyzed neutrophil migration, as a marker of innate immune activation, in zebrafish (Danio rerio) in response to different F.
psychrophilum bath vaccines, which is the first step in evaluating vaccine effectiveness and efficiency in fish.
Results indicated that bacterins of the LM-02-Fp isolate were more immunogenic than those from the LM-13-Fp isolate.
However, no differences were observed between the same bacteria inactivated by either formaldehyde or heat.
Importantly, the same vaccine formulation without an adjuvant only triggered a mild neutrophil migration compared to the complete vaccine.
Observations also found that, after a year of storage at 4°C, the activation of the innate immune system by the different vaccines was considerably decreased.
Finally, new vaccine formulations prepared with heat and formaldehyde inactivated LM-02-Fp were significantly more efficient than the available commercial vaccine in regard to stimulating the innate immune system.
American Psychological Association (APA)
Solís, Camila J.& Poblete-Morales, Matías& Cabral, Sergio& Valdés, Juan A.& Reyes, Ariel E.& Avendaño-Herrera, Ruben…[et al.]. 2015. Neutrophil Migration in the Activation of the Innate Immune Response to Different Flavobacterium psychrophilum Vaccines in Zebrafish (Danio rerio). Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068504
Modern Language Association (MLA)
Solís, Camila J.…[et al.]. Neutrophil Migration in the Activation of the Innate Immune Response to Different Flavobacterium psychrophilum Vaccines in Zebrafish (Danio rerio). Journal of Immunology Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068504
American Medical Association (AMA)
Solís, Camila J.& Poblete-Morales, Matías& Cabral, Sergio& Valdés, Juan A.& Reyes, Ariel E.& Avendaño-Herrera, Ruben…[et al.]. Neutrophil Migration in the Activation of the Innate Immune Response to Different Flavobacterium psychrophilum Vaccines in Zebrafish (Danio rerio). Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068504
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068504