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New Insights about Treg and Th17 Cells in HIV Infection and Disease Progression
Joint Authors
Chies, José Artur
Valverde-Villegas, Jacqueline María
Matte, Maria Cristina Cotta
Medeiros, Rúbia Marília de
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-19
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Treg and Th17 cell subsets are characterized by the expression of specific transcriptional factors and chemokine receptor as well as by secretion of specific cytokine and chemokines.
These subsets are important to the differentiation, expansion, homing capacity, and recruitment of several different immune cell populations to the site of infection.
Whereas Treg cells maintain self-tolerance and control the activation and expansion of autoreactive CD4+ T effector cells through an anti-inflammatory response, Th17 cells, in an exacerbated unregulated proinflammatory response, can promote autoimmunity.
Despite such apparently opposite functions, Th17 and Treg cells share common characteristics, and their differentiation pathways are interconnected.
Recent studies have revealed quite intricate relations between Treg and Th17 cells in HIV infection and progression to AIDS.
Considering Treg cells, different subsets were already investigated in the context of HIV infection, indicating a fluctuation in the total number and frequency throughout the disease course.
This review focuses on the recent findings regarding the role of regulatory T and Th17 cells in the context of HIV infection, highlighting the importance of the balance between these two subsets on disease progression.
American Psychological Association (APA)
Valverde-Villegas, Jacqueline María& Matte, Maria Cristina Cotta& Medeiros, Rúbia Marília de& Chies, José Artur. 2015. New Insights about Treg and Th17 Cells in HIV Infection and Disease Progression. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1068542
Modern Language Association (MLA)
Valverde-Villegas, Jacqueline María…[et al.]. New Insights about Treg and Th17 Cells in HIV Infection and Disease Progression. Journal of Immunology Research No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1068542
American Medical Association (AMA)
Valverde-Villegas, Jacqueline María& Matte, Maria Cristina Cotta& Medeiros, Rúbia Marília de& Chies, José Artur. New Insights about Treg and Th17 Cells in HIV Infection and Disease Progression. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1068542
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068542