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Evaluation of Anti-TBGL Antibody in the Diagnosis of Tuberculosis Patients in China
Joint Authors
Suzuki, Yasuhiko
Zhang, Xiaoyan
Chagan-Yasutan, Haorile
Ashino, Yugo
Hattori, Toshio
Zhao, Jingge
Zhu, Zhaoqin
Chen, Haili
Wan, Yanmin
Xu, Jianqing
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Tuberculous glycolipid (TBGL) is a component of the Mycobacterium tuberculosis cell wall, and anti-TBGL antibodies are used for serodiagnosis of tuberculosis.
Anti-TBGL IgG and IgA levels were measured in 45 pulmonary TB patients (PTB), 26 extra-pulmonary TB patients (ETB), 16 AIDS-TB patients, and 58 healthy controls (HC) including 39 health care workers (HW) and 19 newly enrolled students (ST).
Anti-TBGL IgG measurements yielded 68.9% and 46.2% sensitivity in PTB and ETB, respectively, and 81.0% specificity.
However, anti-TBGL IgA measurements were significantly less sensitive in detecting ETB than PTB (15.4% versus 46.7% sensitivity) but showed up to 89.7% specificity.
Samples from AIDS-TB patients exhibited low reaction of anti-TBGL IgG and IgA with 6.3% and 12.5% sensitivity, respectively.
Unlike anti-lipoarabinomannan (LAM) IgG that was found to elevate in sputum smearpositive subjects, anti-TBGL IgG and IgA elevated in those with cavitation and bronchiectasis, respectively.
Anti-TBGL IgG in cavitary TB yielded 78.2% sensitivity compared to 57.1% in those otherwise.
Meanwhile, higher anti-TBGL IgA titers were observed in HW than in ST, and increasing anti-TBGL IgG titers were observed in HW on follow-up.
Therefore, higher anti-TBGL antibody titers are present in patients presenting cavities and bronchiectasis and subjects under TB exposure risk.
American Psychological Association (APA)
Zhao, Jingge& Zhu, Zhaoqin& Zhang, Xiaoyan& Suzuki, Yasuhiko& Chagan-Yasutan, Haorile& Chen, Haili…[et al.]. 2015. Evaluation of Anti-TBGL Antibody in the Diagnosis of Tuberculosis Patients in China. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068610
Modern Language Association (MLA)
Zhao, Jingge…[et al.]. Evaluation of Anti-TBGL Antibody in the Diagnosis of Tuberculosis Patients in China. Journal of Immunology Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068610
American Medical Association (AMA)
Zhao, Jingge& Zhu, Zhaoqin& Zhang, Xiaoyan& Suzuki, Yasuhiko& Chagan-Yasutan, Haorile& Chen, Haili…[et al.]. Evaluation of Anti-TBGL Antibody in the Diagnosis of Tuberculosis Patients in China. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068610
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068610