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Preparation of Cefquinome Nanoparticles by Using the Supercritical Antisolvent Process
Joint Authors
Kefeng, Xiao
Weiqiang, Wang
Dedong, Hu
Zhihui, Hao
Yanpeng, Qu
Yan, Liu
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The supercritical antisolvent process was used successfully to prepare nanoparticles of cefquinome.
These particles were observed by scanning electron microscope (SEM) and their average diameter was measured by laser particle size analyzer.
In the experiments, dimethyl sulfoxide (DMSO) was selected as solvent to dissolve cefquinome sulfate.
It was confirmed by orthogonal experiments that the concentration of solution was the primary factor in this process followed by feeding speed of solution, precipitation pressure, and precipitation temperature.
Moreover, the optimal conditions of preparing nanoparticles of cefquinome by supercritical antisolvent process were that solution concentration was 100 mg/mL, solution flow speed was 1.5 mL/min, operating pressure was 13 Mpa, and operating temperature was 33°C.
Confirmatory experiment was conducted under this condition.
It was found that the appearance of particles was flakes and the average diameter of particles was 0.71 microns.
Finally, influence law of individual factor on particle size was investigated by univariate analysis.
American Psychological Association (APA)
Kefeng, Xiao& Weiqiang, Wang & Dedong, Hu& Zhihui, Hao& Yanpeng, Qu& Yan, Liu. 2015. Preparation of Cefquinome Nanoparticles by Using the Supercritical Antisolvent Process. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069300
Modern Language Association (MLA)
Kefeng, Xiao…[et al.]. Preparation of Cefquinome Nanoparticles by Using the Supercritical Antisolvent Process. Journal of Nanomaterials No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1069300
American Medical Association (AMA)
Kefeng, Xiao& Weiqiang, Wang & Dedong, Hu& Zhihui, Hao& Yanpeng, Qu& Yan, Liu. Preparation of Cefquinome Nanoparticles by Using the Supercritical Antisolvent Process. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069300