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Nutrition before and during Surgery and the Inflammatory Response of the Heart: A Randomized Controlled Trial
Joint Authors
van Leeuwen, P. A. M.
Niessen, Hans M.
Wisselink, Willem
Visser, Marlieke
Kok, Wouter E. M.
Cocchieri, Riccardo
de Mol, Bas A. J. M.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Major surgery induces a long fasting time and provokes an inflammatory response which increases the risk of infections.
Nutrition given before and during surgery can avoid fasting and has been shown to increase the arginine/asymmetric dimetlhylarginine ratio, a marker of nitric oxide availability, in cardiac tissue and increased concentrations of branched chain amino acids in blood plasma.
However, the effect of this new nutritional strategy on organ inflammatory response is unknown.
Therefore, we studied the effect of nutrition before and during cardiac surgery on myocardial inflammatory response.
In this trial, 32 patients were randomised between enteral, parenteral, and no nutrition supplementation (control) from 2 days before, during, up to 2 days after coronary artery bypass grafting.
Both solutions included proteins or amino acids, glucose, vitamins, and minerals.
Myocardial atrial tissue was sampled before and after revascularization and was analysed immunohistochemically, subdivided into cardiomyocytic, fatty, and fibrotic areas.
Inflammatory cells, especially leukocytes, were present in cardiac tissue in all study groups.
No significant differences were found in the myocardial inflammatory response between the enteral, parenteral, and control groups.
In conclusion, nutrition given before and during surgery neither stimulates nor diminishes the myocardial inflammatory response in patients undergoing coronary artery bypass grafting.
The trial was registered in Netherlands Trial Register (NTR): NTR2183.
American Psychological Association (APA)
Visser, Marlieke& Niessen, Hans M.& Kok, Wouter E. M.& Cocchieri, Riccardo& Wisselink, Willem& van Leeuwen, P. A. M.…[et al.]. 2015. Nutrition before and during Surgery and the Inflammatory Response of the Heart: A Randomized Controlled Trial. Journal of Nutrition and Metabolism،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069506
Modern Language Association (MLA)
Visser, Marlieke…[et al.]. Nutrition before and during Surgery and the Inflammatory Response of the Heart: A Randomized Controlled Trial. Journal of Nutrition and Metabolism No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1069506
American Medical Association (AMA)
Visser, Marlieke& Niessen, Hans M.& Kok, Wouter E. M.& Cocchieri, Riccardo& Wisselink, Willem& van Leeuwen, P. A. M.…[et al.]. Nutrition before and during Surgery and the Inflammatory Response of the Heart: A Randomized Controlled Trial. Journal of Nutrition and Metabolism. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069506
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069506