Maternal Fructose Intake Induces Insulin Resistance and Oxidative Stress in Male, but Not Female, Offspring
Joint Authors
Álvarez-Millán, Juan José
Rodríguez, Lourdes
Otero, Paola
Panadero, María I.
Rodrigo, Silvia
Bocos, Carlos
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Fructose intake from added sugars correlates with the epidemic rise in metabolic syndrome and cardiovascular diseases.
However, consumption of beverages containing fructose is allowed during gestation.
Recently, we found that an intake of fructose (10% wt/vol) throughout gestation produces an impaired fetal leptin signalling.
Therefore, we have investigated whether maternal fructose intake produces subsequent changes in their progeny.
Methods.
Blood samples from fed and 24 h fasted female and male 90-day-old rats born from fructose-fed, glucose-fed, or control mothers were used.
Results.
After fasting, HOMA-IR and ISI (estimates of insulin sensitivity) were worse in male descendents from fructose-fed mothers in comparison to the other two groups, and these findings were also accompanied by a higher leptinemia.
Interestingly, plasma AOPP and uricemia (oxidative stress markers) were augmented in male rats from fructose-fed mothers compared to the animals from control or glucose-fed mothers.
In contrast, female rats did not show any differences in leptinemia between the three groups.
Further, insulin sensitivity was significantly improved in fasted female rats from carbohydrate-fed mothers.
In addition, plasma AOPP levels tended to be diminished in female rats from carbohydrate-fed mothers.
Conclusion.
Maternal fructose intake induces insulin resistance, hyperleptinemia, and plasma oxidative stress in male, but not female, progeny.
American Psychological Association (APA)
Rodríguez, Lourdes& Otero, Paola& Panadero, María I.& Rodrigo, Silvia& Álvarez-Millán, Juan José& Bocos, Carlos. 2015. Maternal Fructose Intake Induces Insulin Resistance and Oxidative Stress in Male, but Not Female, Offspring. Journal of Nutrition and Metabolism،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069508
Modern Language Association (MLA)
Rodríguez, Lourdes…[et al.]. Maternal Fructose Intake Induces Insulin Resistance and Oxidative Stress in Male, but Not Female, Offspring. Journal of Nutrition and Metabolism No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1069508
American Medical Association (AMA)
Rodríguez, Lourdes& Otero, Paola& Panadero, María I.& Rodrigo, Silvia& Álvarez-Millán, Juan José& Bocos, Carlos. Maternal Fructose Intake Induces Insulin Resistance and Oxidative Stress in Male, but Not Female, Offspring. Journal of Nutrition and Metabolism. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069508
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069508