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The Intrauterine and Nursing Period Is a Window of Susceptibility for Development of Obesity and Intestinal Tumorigenesis by a High Fat Diet in Min+ Mice as Adults
Joint Authors
Ngo, Ha Thi
Hetland, Ragna Bogen
Steffensen, Inger-Lise
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-19
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
We studied how obesogenic conditions during various life periods affected obesity and intestinal tumorigenesis in adult C57BL/6J-Min (multiple intestinal neoplasia)/+ mice.
The mice were given a 10% fat diet throughout life (negative control) or a 45% fat diet in utero, during nursing, during both in utero and nursing, during adult life, or during their whole life-span, and terminated at 11 weeks for tumorigenesis (Min/+) or 23 weeks for obesogenic effect (wild-type).
Body weight at 11 weeks was increased after a 45% fat diet during nursing, during both in utero and nursing, and throughout life, but had normalized at 23 weeks.
In the glucose tolerance test, the early exposure to a 45% fat diet in utero, during nursing, or during both in utero and nursing, did not affect blood glucose, whereas a 45% fat diet given to adults or throughout life did.
However, a 45% fat diet during nursing or during in utero and nursing increased the number of small intestinal tumors.
So did exposures to a 45% fat diet in adult life or throughout life, but without increasing the tumor numbers further.
The intrauterine and nursing period is a window of susceptibility for dietary fat-induced obesity and intestinal tumor development.
American Psychological Association (APA)
Ngo, Ha Thi& Hetland, Ragna Bogen& Steffensen, Inger-Lise. 2015. The Intrauterine and Nursing Period Is a Window of Susceptibility for Development of Obesity and Intestinal Tumorigenesis by a High Fat Diet in Min+ Mice as Adults. Journal of Obesity،Vol. 2015, no. 2015, pp.1-25.
https://search.emarefa.net/detail/BIM-1069620
Modern Language Association (MLA)
Ngo, Ha Thi…[et al.]. The Intrauterine and Nursing Period Is a Window of Susceptibility for Development of Obesity and Intestinal Tumorigenesis by a High Fat Diet in Min+ Mice as Adults. Journal of Obesity No. 2015 (2015), pp.1-25.
https://search.emarefa.net/detail/BIM-1069620
American Medical Association (AMA)
Ngo, Ha Thi& Hetland, Ragna Bogen& Steffensen, Inger-Lise. The Intrauterine and Nursing Period Is a Window of Susceptibility for Development of Obesity and Intestinal Tumorigenesis by a High Fat Diet in Min+ Mice as Adults. Journal of Obesity. 2015. Vol. 2015, no. 2015, pp.1-25.
https://search.emarefa.net/detail/BIM-1069620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069620