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Biodegradable 3D-Porous Collagen Matrix (Ologen) Compared with Mitomycin C for Treatment of Primary Open-Angle Glaucoma: Results at 5 Years
Joint Authors
Yuan, Fei
Li, Lei
Chen, Xiuping
Yan, Xiang
Wang, Liyang
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
To evaluate the effectiveness and safety of the Ologen as an aid for trabeculectomy performed for primary open-angle glaucoma compared with mitomycin C.
Methods.
In this prospective, randomized, parallel assignment, comparative study, 31 eyes of 21 primary open-angle glaucoma patients were allocated for trabeculectomy with the Ologen implant; another 32 eyes of 23 patients were treated with trabeculectomy augmented with mitomycin C.
The patients were followed up for 5 years and evaluated for intraocular pressure, rate of success, status of the bleb, and adverse events.
Result.
The mean postoperative intraocular pressure was statistically different at 3 m, 6 m, 1 y, 3 y, and 5 y follow-up.
The rates of both complete success P = 0.017 and overall success P = 0.031 in the Ologen group were significantly higher than those in the mitomycin C group.
The difference of the bleb extent and vascularity was statistically significant in both groups.
There was no significant difference in postoperative complication.
Conclusions.
Ologen provides higher rates of surgical success compared with mitomycin C for patients with primary open-angle glaucoma undergoing trabeculectomy.
It may be a new, safe, simple, and effective therapeutic approach for treating primary open-angle glaucoma.
American Psychological Association (APA)
Yuan, Fei& Li, Lei& Chen, Xiuping& Yan, Xiang& Wang, Liyang. 2015. Biodegradable 3D-Porous Collagen Matrix (Ologen) Compared with Mitomycin C for Treatment of Primary Open-Angle Glaucoma: Results at 5 Years. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069798
Modern Language Association (MLA)
Yuan, Fei…[et al.]. Biodegradable 3D-Porous Collagen Matrix (Ologen) Compared with Mitomycin C for Treatment of Primary Open-Angle Glaucoma: Results at 5 Years. Journal of Ophthalmology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1069798
American Medical Association (AMA)
Yuan, Fei& Li, Lei& Chen, Xiuping& Yan, Xiang& Wang, Liyang. Biodegradable 3D-Porous Collagen Matrix (Ologen) Compared with Mitomycin C for Treatment of Primary Open-Angle Glaucoma: Results at 5 Years. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069798
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069798