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The Effect of Rebamipide on Ocular Surface Disorders Induced by Latanoprost and Timolol in Glaucoma Patients
Joint Authors
Munemasa, Yasunari
Tokuda, Naoto
Kitaoka, Yasushi
Matsuzawa, Akiko
Miyamoto, Junsuke
Sakae, Shinsuke
Takagi, Hitoshi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
To examine the efficacy of ophthalmic rebamipide suspensions on ocular surface disorders induced by antiglaucoma eye drops.
Patients and Methods.
Forty eyes of 40 patients receiving latanoprost (0.005%) and timolol (0.5%) were included in this randomized prospective study.
The patients were randomly divided into two groups (n = 20): the rebamipide-treated group and controlgroup.
Changes in intraocular pressure, tear film break-up time (TBUT), and corneal epithelial barrier function were evaluated at baseline, 4 weeks, and 8 weeks after rebamipide administration.
Furthermore, superficial punctate keratopathy severity was evaluated by scoring the lesion area and density.
Results.
There was no significant difference in intraocular pressure before and after rebamipide treatment.
However, corneal epithelial barrier function improved significantly 4 and 8 weeks after rebamipide treatment.
TBUT was partially, but significantly, increased (P = 0.02) 8 weeks after rebamipide treatment, whereas no significant change was observed at 4 weeks.
Additionally, a significant decrease in area and density of keratopathy was observed 8 weeks after rebamipide treatment but not at 4 weeks.
The control group showed no significant difference compared to baseline.
Conclusions.
Our data suggests that rebamipide treatment may reduce the occurrence of drug-induced ocular surface disorder.
American Psychological Association (APA)
Tokuda, Naoto& Kitaoka, Yasushi& Matsuzawa, Akiko& Miyamoto, Junsuke& Sakae, Shinsuke& Munemasa, Yasunari…[et al.]. 2015. The Effect of Rebamipide on Ocular Surface Disorders Induced by Latanoprost and Timolol in Glaucoma Patients. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1069811
Modern Language Association (MLA)
Tokuda, Naoto…[et al.]. The Effect of Rebamipide on Ocular Surface Disorders Induced by Latanoprost and Timolol in Glaucoma Patients. Journal of Ophthalmology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1069811
American Medical Association (AMA)
Tokuda, Naoto& Kitaoka, Yasushi& Matsuzawa, Akiko& Miyamoto, Junsuke& Sakae, Shinsuke& Munemasa, Yasunari…[et al.]. The Effect of Rebamipide on Ocular Surface Disorders Induced by Latanoprost and Timolol in Glaucoma Patients. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1069811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069811