Aqueous Levels of Pigment Epithelium-Derived Factor and Macular Choroidal Thickness in High Myopia
Joint Authors
Song, Hui
Chen, Wei
Guan, Yubo
He, Guanghui
Xie, Shiyong
Han, Quanhong
Li, Zhiwei
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
To investigate the correlation between aqueous and serum levels of pigment epithelium-derived factor (PEDF) and macular choroidal thickness in high myopia patients, both with and without choroidal neovascularization (CNV).
Methods.
Serum and aqueous levels of PEDF were measured by enzyme-linked immunosorbent assay in 36 high myopia patients (36 eyes) with no CNV (non-CNV group), 14 high myopia patients (14 eyes) with CNV (CNV group), and 42 nonmyopia patients (42 eyes) (control group).
Macular choroidal thickness was measured by enhanced-depth imaging optical coherence tomography.
Results.
Aqueous levels of PEDF were significantly higher in CNV group compared with non-CNV (P<0.001) and control (P<0.001) groups.
Macular choroidal thicknesses were significantly decreased in the non-CNV and CNV groups compared with the control (P<0.001) group.
A statistically significant difference (P=0.012) was found between the CNV and non-CNV groups.
There was a positive correlation between aqueous PEDF and macular choroidal thickness in the non-CNV group (P=0.005), but no correlation with the CNV group.
No correlation between serum PEDF and macular choroidal thickness was detected in the three groups.
Conclusion.
Variations in aqueous PEDF levels coincide with changes in macular choroidal thickness in high myopia patients with no CNV, while no such relationship exists in high myopia patients with CNV.
American Psychological Association (APA)
Chen, Wei& Guan, Yubo& He, Guanghui& Li, Zhiwei& Song, Hui& Xie, Shiyong…[et al.]. 2015. Aqueous Levels of Pigment Epithelium-Derived Factor and Macular Choroidal Thickness in High Myopia. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069822
Modern Language Association (MLA)
Chen, Wei…[et al.]. Aqueous Levels of Pigment Epithelium-Derived Factor and Macular Choroidal Thickness in High Myopia. Journal of Ophthalmology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1069822
American Medical Association (AMA)
Chen, Wei& Guan, Yubo& He, Guanghui& Li, Zhiwei& Song, Hui& Xie, Shiyong…[et al.]. Aqueous Levels of Pigment Epithelium-Derived Factor and Macular Choroidal Thickness in High Myopia. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069822
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069822