Relationship between Clinical and Immunological Features of Thyroid Autoimmunity and Ophthalmopathy during Pregnancy
Joint Authors
Wall, Jack R.
Lahooti, Hooshang
Hibbert, Emily J.
Champion, Bernard
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Problem.
Clinical features of Graves’ hyperthyroidism (GH) generally improve during pregnancy and rebound in the postpartum period.
It is unclear whether the ophthalmopathy that is associated with GH and, less often, Hashimoto’s thyroiditis (HT) changes in parallel with the thyroid associated antibody reactions and clinical features or runs a different course.
Method of Study.
We retrospectively studied 19 patients with autoimmune thyroid disease over 22 pregnancies: 9 pregnancies with GH and 13 with HT.
Ophthalmopathy was defined by NOSPECS class.
Results.
Thyroid peroxidase (TPO) and thyroglobulin (Tg) antibody titres decreased during pregnancy and rose in the postpartum period.
During pregnancy, 5 patients with GH and 4 patients with HT developed mild ophthalmopathy and two patients with GH and HT developed new upper eyelid retraction (UER).
In the postpartum period, eye scores improved in 3 patients with GH and 3 with HT, remained stable in two and 5 patients, respectively, and worsened in 2 patients with GH and one with HT.
Conclusions.
In patients with mild to moderate eye signs associated with GH and HT, the orbital and thyroid reactions ran different courses during pregnancy.
Since no patient had severe ophthalmopathy, we cannot draw definitive conclusions from this preliminary study.
American Psychological Association (APA)
Wall, Jack R.& Lahooti, Hooshang& Hibbert, Emily J.& Champion, Bernard. 2015. Relationship between Clinical and Immunological Features of Thyroid Autoimmunity and Ophthalmopathy during Pregnancy. Journal of Thyroid Research،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1070428
Modern Language Association (MLA)
Wall, Jack R.…[et al.]. Relationship between Clinical and Immunological Features of Thyroid Autoimmunity and Ophthalmopathy during Pregnancy. Journal of Thyroid Research No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1070428
American Medical Association (AMA)
Wall, Jack R.& Lahooti, Hooshang& Hibbert, Emily J.& Champion, Bernard. Relationship between Clinical and Immunological Features of Thyroid Autoimmunity and Ophthalmopathy during Pregnancy. Journal of Thyroid Research. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1070428
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1070428