ADAMTS-7 Exhibits Elevated Expression in Cartilage of Osteonecrosis of Femoral Head and Has a Positive Correlation with TNF- α and NF- κB P65
Joint Authors
Li, Jing-kun
Cheng, Lei
Zhao, Yun-peng
Guo, Ying-jun
Liu, Yi
Zhang, Wei
Wang, Shuai-shuai
Zhang, Yuan-qiang
Pan, Xin
Nie, Lin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
ADAMTS-7 has been reported to exaggerate cartilage degeneration and to be associated with TNF-α and NF-κB signaling pathway.
In this study we compared the expression of ADAMTS-7, TNF-α, and Phospho-NF-κB in patients with femoral neck fracture (FNF) and osteonecrosis of femoral head (ONFH) at different stages.
We found that expression of ADAMTS-7, TNF-α, and Phospho-NF-κB was significantly upregulated in ONFH patients’ articular cartilage and related to the pathogenesis of ONFH.
Thus we conclude that ADAMTS-7 level appears to be positively associated with expression of TNF-α and Phospho-NF-κB P65 in cartilage, which may imply its association with cartilage destruction of ONFH.
American Psychological Association (APA)
Li, Jing-kun& Cheng, Lei& Zhao, Yun-peng& Guo, Ying-jun& Liu, Yi& Zhang, Wei…[et al.]. 2015. ADAMTS-7 Exhibits Elevated Expression in Cartilage of Osteonecrosis of Femoral Head and Has a Positive Correlation with TNF- α and NF- κB P65. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072178
Modern Language Association (MLA)
Li, Jing-kun…[et al.]. ADAMTS-7 Exhibits Elevated Expression in Cartilage of Osteonecrosis of Femoral Head and Has a Positive Correlation with TNF- α and NF- κB P65. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072178
American Medical Association (AMA)
Li, Jing-kun& Cheng, Lei& Zhao, Yun-peng& Guo, Ying-jun& Liu, Yi& Zhang, Wei…[et al.]. ADAMTS-7 Exhibits Elevated Expression in Cartilage of Osteonecrosis of Femoral Head and Has a Positive Correlation with TNF- α and NF- κB P65. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072178
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072178