Systemic Inflammatory Markers Are Closely Associated with Atherogenic Lipoprotein Subfractions in Patients Undergoing Coronary Angiography
Joint Authors
Guo, Yuan-Lin
Li, Jianjun
Zhang, Yan
Li, Sha
Xu, Rui-Xia
Zhu, Cheng-Gang
Wu, Na-Qiong
Sun, Jing
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To investigate the relationship between inflammatory markers and atherogenic lipoprotein subfractions.
Methods.
We studied 520 eligible subjects who were not receiving any lipid-lowering therapy.
The inflammatory markers including white blood cell (WBC) count, high-sensitivity C-reactive protein (hs-CRP), fibrinogen, erythrocyte sedimentation rate (ESR), and D-dimer were measured.
A multimarker inflammatory index was developed.
Low-density lipoprotein (LDL) and high-density lipoprotein (HDL) separation processes were performed using Lipoprint System.
Results.
In age- and sex-adjusted analysis, several inflammatory markers (WBC count, hs-CRP, fibrinogen, and ESR) were positively related to circulating non-HDL cholesterol and remnant cholesterol ( p < 0.05 , all).
Among lipoprotein subfractions, we observed a positive association of inflammatory markers with very low-density lipoprotein cholesterol, small LDL cholesterol, and LDL score ( p < 0.05 , all).
Meanwhile, a negative association was detected between inflammatory markers and mean LDL particle size ( p < 0.05 ) or large HDL cholesterol ( p < 0.05 ).
Moreover, we found that the relationships between multimarker index quartiles and small LDL cholesterol, LDL score, and mean LDL particle size were slightly stronger in patients with CAD.
Conclusions.
Systemic inflammatory markers are positively correlated with small LDL cholesterol and LDL score while being negatively linked with mean LDL particle size and large HDL cholesterol, highlighting the potential contribution to increased cardiovascular risk.
American Psychological Association (APA)
Zhang, Yan& Li, Sha& Xu, Rui-Xia& Zhu, Cheng-Gang& Guo, Yuan-Lin& Wu, Na-Qiong…[et al.]. 2015. Systemic Inflammatory Markers Are Closely Associated with Atherogenic Lipoprotein Subfractions in Patients Undergoing Coronary Angiography. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072192
Modern Language Association (MLA)
Zhang, Yan…[et al.]. Systemic Inflammatory Markers Are Closely Associated with Atherogenic Lipoprotein Subfractions in Patients Undergoing Coronary Angiography. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072192
American Medical Association (AMA)
Zhang, Yan& Li, Sha& Xu, Rui-Xia& Zhu, Cheng-Gang& Guo, Yuan-Lin& Wu, Na-Qiong…[et al.]. Systemic Inflammatory Markers Are Closely Associated with Atherogenic Lipoprotein Subfractions in Patients Undergoing Coronary Angiography. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072192
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072192