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Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments
Joint Authors
Bier, Julia
Paiatto, Lisiery Negrini
Galdino Albuquerque, Cassia
Lopes Souza, Caique
Fernandes, Luis Gustavo Romani
de Mattos, Bruno Rafael Ramos
Garcia, Maellin Pereira Gracindo
Tamashiro, Wirla Maria da Silva Cunha
Simioni, Patricia Ucelli
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the intestinal tract associated with an imbalance of the intestinal microbiota.
Crohn’s disease (CD) and ulcerative colitis (UC) are the most widely known types of IBD and have been the focus of attention due to their increasing incidence.
Recent studies have pointed out genes associated with IBD susceptibility that, together with environment factors, may contribute to the outcome of the disease.
In ulcerative colitis, there are several therapies available, depending on the stage of the disease.
Aminosalicylates, corticosteroids, and cyclosporine are used to treat mild, moderate, and severe disease, respectively.
In Crohn’s disease, drug choices are dependent on both location and behavior of the disease.
Nowadays, advances in treatments for IBD have included biological therapies, based mainly on monoclonal antibodies or fusion proteins, such as anti-TNF drugs.
Notwithstanding the high cost involved, these biological therapies show a high index of remission, enabling a significant reduction in cases of surgery and hospitalization.
Furthermore, migration inhibitors and new cytokine blockers are also a promising alternative for treating patients with IBD.
In this review, an analysis of literature data on biological treatments for IBD is approached, with the main focus on therapies based on emerging recombinant biomolecules.
American Psychological Association (APA)
de Mattos, Bruno Rafael Ramos& Garcia, Maellin Pereira Gracindo& Bier, Julia& Paiatto, Lisiery Negrini& Galdino Albuquerque, Cassia& Lopes Souza, Caique…[et al.]. 2015. Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072384
Modern Language Association (MLA)
de Mattos, Bruno Rafael Ramos…[et al.]. Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072384
American Medical Association (AMA)
de Mattos, Bruno Rafael Ramos& Garcia, Maellin Pereira Gracindo& Bier, Julia& Paiatto, Lisiery Negrini& Galdino Albuquerque, Cassia& Lopes Souza, Caique…[et al.]. Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072384
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072384