25-OH Vitamin D and Interleukin-8: Emerging Biomarkers in Cutaneous Melanoma Development and Progression

Abstract EN

Background.

There are several circulatory biomarkers that are involved in forecasting the clinical outcome of cutaneous melanoma.

Serum/plasma vitamin D status is one of the markers intensively studied in this type of cutaneous cancer.

The combination of validated serum biomarkers (like LDH) with new biomarkers such as IL-8, angiogenic factor, and vitamin D is still at the dawn of research.

Hence, we are aiming to establish the predictive power of inflammatory biomarkers, such as IL-8, and metabolic ones, such as vitamin D.

These candidate biomarkers are intended to aid classical biomarkers, such as LDH, in the prognosis of cutaneous melanoma.

Methods.

Serum vitamin D and IL-8 were quantified in melanoma patients and in matching healthy controls.

Results.

Median serum vitamin D concentrations were significantly lower (p=0.003) in melanoma patients as compared to healthy control subjects, while around 65% of the investigated patients have proven a severe circulatory deficiency of this vitamin.

IL-8 was found increased (p=0.001) in melanoma patients as compared to controls.

Conclusion.

Upregulation of proangiogenic factors associated with vitamin D deficiency can prove to be potent future biomarkers candidates, enhancing the predictive power of classical LDH.