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Prophylactic Subacute Administration of Zinc Increases CCL2, CCR2, FGF2, and IGF-1 Expression and Prevents the Long-Term Memory Loss in a Rat Model of Cerebral Hypoxia-Ischemia
Joint Authors
Blanco-Alvarez, Victor Manuel
Martinez-Fong, Daniel
Gonzalez-Barrios, Juan Antonio
Brambila, Eduardo
Soto-Rodriguez, Guadalupe
Aguilar-Peralta, Ana Karina
Gonzalez-Vazquez, Alejandro
Tomás-Sanchez, Constantino
Limón, I. Daniel
Eguibar, Jose R.
Hernandez-Castillo, Jeanett
Torres-Soto, Maricela
Ugarte, Araceli
Leon-Chavez, Bertha Alicia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-18
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Prophylactic subacute administration of zinc decreases lipoperoxidation and cell death following a transient cerebral hypoxia-ischemia, thus suggesting neuroprotective and preconditioning effects.
Chemokines and growth factors are also involved in the neuroprotective effect in hypoxia-ischemia.
We explored whether zinc prevents the cerebral cortex-hippocampus injury through regulation of CCL2, CCR2, FGF2, and IGF-1 expression following a 10 min of common carotid artery occlusion (CCAO).
Male rats were grouped as follows: (1) Zn96h, rats injected with ZnCl2 (one dose every 24 h during four days); (2) Zn96h + CCAO, rats treated with ZnCl2 before CCAO; (3) CCAO, rats with CCAO only; (4) Sham group, rats with mock CCAO; and (5) untreated rats.
The cerebral cortex-hippocampus was dissected at different times before and after CCAO.
CCL2/CCR2, FGF2, and IGF-1 expression was assessed by RT-PCR and ELISA.
Learning in Morris Water Maze was achieved by daily training during 5 days.
Long-term memory was evaluated on day 7 after learning.
Subacute administration of zinc increased expression of CCL2, CCR2, FGF2, and IGF-1 in the early and late phases of postreperfusion and prevented the CCAO-induced memory loss in the rat.
These results might be explained by the induction of neural plasticity because of the expression of CCL2 and growth factors.
American Psychological Association (APA)
Blanco-Alvarez, Victor Manuel& Soto-Rodriguez, Guadalupe& Gonzalez-Barrios, Juan Antonio& Martinez-Fong, Daniel& Brambila, Eduardo& Torres-Soto, Maricela…[et al.]. 2015. Prophylactic Subacute Administration of Zinc Increases CCL2, CCR2, FGF2, and IGF-1 Expression and Prevents the Long-Term Memory Loss in a Rat Model of Cerebral Hypoxia-Ischemia. Neural Plasticity،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1075331
Modern Language Association (MLA)
Blanco-Alvarez, Victor Manuel…[et al.]. Prophylactic Subacute Administration of Zinc Increases CCL2, CCR2, FGF2, and IGF-1 Expression and Prevents the Long-Term Memory Loss in a Rat Model of Cerebral Hypoxia-Ischemia. Neural Plasticity No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1075331
American Medical Association (AMA)
Blanco-Alvarez, Victor Manuel& Soto-Rodriguez, Guadalupe& Gonzalez-Barrios, Juan Antonio& Martinez-Fong, Daniel& Brambila, Eduardo& Torres-Soto, Maricela…[et al.]. Prophylactic Subacute Administration of Zinc Increases CCL2, CCR2, FGF2, and IGF-1 Expression and Prevents the Long-Term Memory Loss in a Rat Model of Cerebral Hypoxia-Ischemia. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1075331
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075331