N-Acetylcysteine for Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Joint Authors
Thakker, Divyesh
Patel, Isha
Walia, Rama
Raval, Amit D.
Source
Obstetrics and Gynecology International
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Objective.
To review the benefits and harms of N-acetylcysteine (NAC) in women with polycystic ovary syndrome (PCOS).
Method.
Literature search was conducted using the bibliographic databases, MEDLINE (Ovid), CINAHL, EMBASE, Scopus, PsyInfo, and PROQUEST (from inception to September 2013) for the studies on women with PCOS receiving NAC.
Results.
Eight studies with a total of 910 women with PCOS were randomized to NAC or other treatments/placebo.
There were high risk of selection, performance, and attrition bias in two studies and high risk of reporting bias in four studies.
Women with NAC had higher odds of having a live birth, getting pregnant, and ovulation as compared to placebo.
However, women with NAC were less likely to have pregnancy or ovulation as compared to metformin.
There was no significant difference in rates of the miscarriage, menstrual regulation, acne, hirsutism, and adverse events, or change in body mass index, testosterone, and insulin levels with NAC as compared to placebo.
Conclusions.
NAC showed significant improvement in pregnancy and ovulation rate as compared to placebo.
The findings need further confirmation in well-designed randomized controlled trials to examine clinical outcomes such as live birth rate in longer follow-up periods.
Systematic review registration number is CRD42012001902.
American Psychological Association (APA)
Thakker, Divyesh& Raval, Amit D.& Patel, Isha& Walia, Rama. 2015. N-Acetylcysteine for Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials. Obstetrics and Gynecology International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075514
Modern Language Association (MLA)
Thakker, Divyesh…[et al.]. N-Acetylcysteine for Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials. Obstetrics and Gynecology International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1075514
American Medical Association (AMA)
Thakker, Divyesh& Raval, Amit D.& Patel, Isha& Walia, Rama. N-Acetylcysteine for Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials. Obstetrics and Gynecology International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075514
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075514