Circadian System and Melatonin Hormone: Risk Factors for Complications during Pregnancy
Joint Authors
Vera, J.
Venegas, C.
Pino, F.
Lagunas, C.
Valenzuela, Francisco J.
Source
Obstetrics and Gynecology International
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Pregnancy is a complex and well-regulated temporal event in which several steps are finely orchestrated including implantation, decidualization, placentation, and partum and any temporary alteration has serious effects on fetal and maternal health.
Interestingly, alterations of circadian rhythms (i.e., shiftwork) have been correlated with increased risk of preterm delivery, intrauterine growth restriction, and preeclampsia.
In the last few years evidence is accumulating that the placenta may have a functional circadian system and express the clock genes Bmal1, Per1-2, and Clock.
On the other hand, there is evidence that the human placenta synthesizes melatonin, hormone involved in the regulation of the circadian system in other tissues.
Moreover, is unknown the role of this local production of melatonin and whether this production have a circadian pattern.
Available information indicates that melatonin induces in placenta the expression of antioxidant enzymes catalase and superoxide dismutase, prevents the injury produced by oxidative stress, and inhibits the expression of vascular endothelial growth factor (VEGF) a gene that in other tissues is controlled by clock genes.
In this review we aim to analyze available information regarding clock genes and clock genes controlled genes such as VEGF and the possible role of melatonin synthesis in the placenta.
American Psychological Association (APA)
Valenzuela, Francisco J.& Vera, J.& Venegas, C.& Pino, F.& Lagunas, C.. 2015. Circadian System and Melatonin Hormone: Risk Factors for Complications during Pregnancy. Obstetrics and Gynecology International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075515
Modern Language Association (MLA)
Valenzuela, Francisco J.…[et al.]. Circadian System and Melatonin Hormone: Risk Factors for Complications during Pregnancy. Obstetrics and Gynecology International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075515
American Medical Association (AMA)
Valenzuela, Francisco J.& Vera, J.& Venegas, C.& Pino, F.& Lagunas, C.. Circadian System and Melatonin Hormone: Risk Factors for Complications during Pregnancy. Obstetrics and Gynecology International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075515
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075515