Relationship between Inflammation and Oxidative Stress and Cognitive Decline in the Institutionalized Elderly
Joint Authors
Baierle, Marília
Nascimento, Sabrina N.
Moro, Angela M.
Brucker, Natália
Freitas, Fernando
Gauer, Bruna
Durgante, Juliano
Bordignon, Suelen
Zibetti, Murilo
Trentini, Clarissa M.
Grune, Tilman
Breusing, Nicolle
Garcia, Solange C.
Medeiros Frescura Duarte, Marta Maria
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
Cognitive impairment reduces quality of life and is related to vascular and neurodegenerative disorders.
However, there is also a close relationship between these diseases and oxidative stress.
Thus, the purpose of this study was to assess whether inflammation and oxidative damage are associated with low cognitive performance in the elderly with different housing conditions.
Methods.
The study groups consisted of 32 institutionalized and 25 noninstitutionalized Brazilian elderly subjects.
Oxidative damage, inflammation markers, and cognitive function were evaluated.
Results.
The results demonstrated pronounced oxidative stress in the institutionalized elderly group, which also had a lower antioxidant status compared to noninstitutionalized subjects.
High levels of proinflammatory cytokines were also observed in the institutionalized elderly.
Furthermore, the raised levels of inflammatory markers were correlated with increased oxidative stress, and both were associated with low cognitive performance.
However, based on multiple linear regression analysis, oxidative stress appears to be the main factor responsible for the cognitive decline.
Conclusions.
The findings suggest that individuals with lower antioxidant status are more vulnerable to oxidative stress, which is associated with cognitive function, leading to reduced life quality and expectancy.
American Psychological Association (APA)
Baierle, Marília& Nascimento, Sabrina N.& Moro, Angela M.& Brucker, Natália& Freitas, Fernando& Gauer, Bruna…[et al.]. 2015. Relationship between Inflammation and Oxidative Stress and Cognitive Decline in the Institutionalized Elderly. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075781
Modern Language Association (MLA)
Baierle, Marília…[et al.]. Relationship between Inflammation and Oxidative Stress and Cognitive Decline in the Institutionalized Elderly. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1075781
American Medical Association (AMA)
Baierle, Marília& Nascimento, Sabrina N.& Moro, Angela M.& Brucker, Natália& Freitas, Fernando& Gauer, Bruna…[et al.]. Relationship between Inflammation and Oxidative Stress and Cognitive Decline in the Institutionalized Elderly. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075781
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075781