Atypical Small Acinar Proliferation: Repeat Biopsy and Detection of High Grade Prostate Cancer
Joint Authors
Amin, Ali
Leone, Andrew
Rotker, Katherine
Butler, Christi
Mega, Anthony
Li, Jianhong
Schiff, Stephen F.
Pareek, Gyan
Golijanin, Dragan
Renzulli, Joseph F.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
Atypical small acinar proliferation (ASAP) is diagnosed in 1-2% of prostate biopsies.
30–40% of patients with ASAP may be diagnosed with prostate cancer (PCa) on repeat biopsy.
Our objective was to examine the association between ASAP and subsequent diagnosis of intermediate/high risk PCa.
Materials and Methods.
Ninety-six patients who underwent prostate biopsy from 2000 to 2013 and were diagnosed with ASAP were identified.
Clinicopathologic features were analyzed.
Comparison was made between those with subsequent PCa on repeat biopsy and those with benign repeat pathology.
Results.
56/96 (58%) patients had a repeat biopsy.
22/56 (39%) were subsequently diagnosed with PCa.
There was no significant difference in patients’ characteristics.
Presence of HGPIN on initial biopsy was associated with a benign repeat biopsy (68% versus 23%).
17/22 (77%) had Gleason grade (GG) 3+3 disease and only 5/22 (23%) had GG 3+4 disease.
Conclusions.
22/56 patients (39%) of patients who underwent a subsequent prostate biopsy following a diagnosis of ASAP were found to have PCa.
77% of these men were diagnosed with GG 3+3 PCa.
Only 23% were found to have intermediate risk PCa and no high risk PCa was identified.
Immediate repeat prostate biopsy in patients diagnosed with ASAP may be safely delayed.
A multi-institutional cohort is being analyzed.
American Psychological Association (APA)
Leone, Andrew& Rotker, Katherine& Butler, Christi& Mega, Anthony& Li, Jianhong& Amin, Ali…[et al.]. 2015. Atypical Small Acinar Proliferation: Repeat Biopsy and Detection of High Grade Prostate Cancer. Prostate Cancer،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1075841
Modern Language Association (MLA)
Leone, Andrew…[et al.]. Atypical Small Acinar Proliferation: Repeat Biopsy and Detection of High Grade Prostate Cancer. Prostate Cancer No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1075841
American Medical Association (AMA)
Leone, Andrew& Rotker, Katherine& Butler, Christi& Mega, Anthony& Li, Jianhong& Amin, Ali…[et al.]. Atypical Small Acinar Proliferation: Repeat Biopsy and Detection of High Grade Prostate Cancer. Prostate Cancer. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1075841
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075841