Altered Brain Activation in Early Drug-Naive Parkinson’s Disease during Heat Pain Stimuli: An fMRI Study
Joint Authors
Yao, Dezhong
Luo, Cheng
Tan, Ying
Tan, Juan
Cui, Wenjuan
He, Hui
Bin, Yi
Deng, Jiayan
Tan, Rui
Tan, Wenrong
Liu, Tao
Zeng, Nanlin
Xiao, Ruhui
Wang, Xiaoming
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by motor and nonmotor signs and symptoms.
To date, many studies of PD have focused on its cardinal motor symptoms.
To study the nonmotor signs of early PD, we investigated the reactions solicited by heat pain stimuli in early untreated PD patients without pain using fMRI.
The activation patterns of contact heat stimuli (51°C) were assessed in 14 patients and 17 age- and sex-matched healthy controls.
Patients with PD showed significant decreases in activation of the superior temporal gyrus (STG) and insula compared with controls.
In addition, a significant relationship between activation of the insula and STG and the pain scores was observed in healthy controls but not in PD.
This study provided further support that the insula and STG are important parts of the somatosensory circuitry recruited during the period of pain.
The hypoactivity of the STG and insula in PD implied that functions including affective, cognitive, and sensory-discriminative processes, which are associated with the insula and STG, were disturbed.
This finding supports the view that leaving early PD untreated could be tied directly to central nervous system dysfunction.
American Psychological Association (APA)
Tan, Ying& Tan, Juan& Luo, Cheng& Cui, Wenjuan& He, Hui& Bin, Yi…[et al.]. 2015. Altered Brain Activation in Early Drug-Naive Parkinson’s Disease during Heat Pain Stimuli: An fMRI Study. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075860
Modern Language Association (MLA)
Tan, Ying…[et al.]. Altered Brain Activation in Early Drug-Naive Parkinson’s Disease during Heat Pain Stimuli: An fMRI Study. Parkinson’s Disease No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075860
American Medical Association (AMA)
Tan, Ying& Tan, Juan& Luo, Cheng& Cui, Wenjuan& He, Hui& Bin, Yi…[et al.]. Altered Brain Activation in Early Drug-Naive Parkinson’s Disease during Heat Pain Stimuli: An fMRI Study. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075860
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075860