Anti-diabetic effects and lipid profile for abelmoschus esculentus (okra)‎ and corchorus olitorius (Jew's mallow)‎ caused by streptozotocin in rats

Abstract EN

The present study was directed to use Abelmoschus esculentus (Okra) and Corchorus olitorius (Jew's mallow) as a source of dietary fiber in order to study the biological effect of such materials which were used in the experimental diets for streptozotocin-induced diabetic rats.

Rats were made diabetic by injecting streptozotocin into leg muscle at dose of 50 mg/kg body weight.

Diabetic rats were (28 rats) divided into 4 groups (7 rats each group).

The first group was negative control group (NC), the second group was diabetic positive control (PC), the third one was 10 % Corchorus olitorius (Jew's mallow) group (COJ), and the fourth was 10 % Abelmoschus esculentus (Okra) group (AEO).

Blood samples were collected weekly for glucose monitoring while blood lipids were measured at the end of the experiment.

The study was assigned for 4 weeks.

The results revealed that, the treatment with Abelmoschus esculentus (Okra) and Corchorus olitorius (Jew's mallow) showed significantly decreased of serum glucose level of all the experimental groups.

Meanwhile, no significant differences were recorded among blood indices of these groups, i.

e.

serum total cholesterol, total triglycerides, HDL-c, LDL-c, VLDL-c, at zero time.

But after induced hyperglycemia, there were noticeable decrease in TC(total cholesterol level), TG, and LDL, while increase HDL.

Maximum significant significant decreased was seen in rats fed on Abelmoschus esculentus followed by rats fed on Corchorus olitoriusRecommendation: The study recommends eating Abelmoschus esculentus (Okra) and Corchorus olitorius (Jew's mallow)or adding to the foods that have a positive effect to treat Diabetes mellitus.

Because of its high in insoluble DF might significantly reduce diabetes risk.

Key words: Diabetic, Lipid profile Abelmoschus esculentus (Okra), Corchorus olitorius (Jew's mallow) Streptozotocin, rats